Gene interactions and pathways from curated databases and text-mining

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PDCD4 — TNFSF10

Text-mined interactions from Literome

Tanaka et al., Hepatology 2000 (Bile Duct Neoplasms...) : Recombinant TRAIL induced extensive programmed cell death in cholangiocarcinoma cell lines lacking decoy receptor expression
Atkins et al., Bone 2002 (Osteoarthritis) : Apo2L/TRAIL can selectively induce programmed cell death in transformed cells, although its wide tissue distribution suggests potential physiological roles
Shivapurkar et al., Int J Cancer 2004 (Breast Neoplasms...) : TNF related apoptosis inducing ligand ( TRAIL ) selectively induces programmed cell death ( apoptosis ) in various cancer cells but not in normal cells
Varfolomeev et al., J Biol Chem 2005 : Apo2 ligand/tumor necrosis factor (TNF) related apoptosis inducing ligand ( Apo2L/TRAIL ) mainly activates programmed cell death through caspases
Briggs et al., Cancer Res 2006 (Myelodysplastic Syndromes) : We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL induced programmed cell death
Krieg et al., Biochem Biophys Res Commun 2006 : In conclusion, alternative splicing might be involved in functional fine tuning of TRAIL induced programmed cell death
Ying et al., Leukemia & lymphoma 2007 (Leukemia, Myeloid) : Thus, the effect of bexarotene on TRAIL mediated programmed cell death involved proximal events of the extrinsic pathway ; however, downstream signals involved the intrinsic pathway in ML-1 but not in KG1a cells
Zahn et al., Br J Dermatol 2011 (Lupus Erythematosus, Cutaneous) : The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation, and TRAIL may trigger this programmed cell death
El-Karaksy et al., Gene 2013 (Lupus Erythematosus, Systemic) : The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE, and TRAIL may trigger this programmed cell death