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PDCD4 — TNFSF10
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Tanaka et al., Hepatology 2000
(Bile Duct Neoplasms...) :
Recombinant
TRAIL induced extensive
programmed cell death in cholangiocarcinoma cell lines lacking decoy receptor expression
Atkins et al., Bone 2002
(Osteoarthritis) :
Apo2L/TRAIL can selectively
induce programmed cell death in transformed cells, although its wide tissue distribution suggests potential physiological roles
Shivapurkar et al., Int J Cancer 2004
(Breast Neoplasms...) :
TNF related apoptosis inducing ligand ( TRAIL ) selectively
induces programmed cell death ( apoptosis ) in various cancer cells but not in normal cells
Varfolomeev et al., J Biol Chem 2005
:
Apo2 ligand/tumor necrosis factor
(TNF) related apoptosis inducing ligand ( Apo2L/TRAIL ) mainly
activates programmed cell death through caspases
Briggs et al., Cancer Res 2006
(Myelodysplastic Syndromes) :
We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to
TRAIL induced
programmed cell death
Krieg et al., Biochem Biophys Res Commun 2006
:
In conclusion, alternative splicing might be involved in functional fine tuning of
TRAIL induced
programmed cell death
Ying et al., Leukemia & lymphoma 2007
(Leukemia, Myeloid) :
Thus, the effect of bexarotene on
TRAIL mediated
programmed cell death involved proximal events of the extrinsic pathway ; however, downstream signals involved the intrinsic pathway in ML-1 but not in KG1a cells
Zahn et al., Br J Dermatol 2011
(Lupus Erythematosus, Cutaneous) :
The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation, and
TRAIL may
trigger this
programmed cell death
El-Karaksy et al., Gene 2013
(Lupus Erythematosus, Systemic) :
The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE, and
TRAIL may
trigger this
programmed cell death