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CD2 — IL10

Text-mined interactions from Literome

Taylor et al., Mol Immunol 2009 : Here, we demonstrate that IL-10 directly inhibits CD2 signaling in T cells
de Waal Malefyt et al., J Immunol 1993 : IL-10 did not affect the expression of the TCR/CD3 complex, CD2 , LFA-1, CD28, or IL-2R alpha- or beta-chains, nor did it inhibit the induction of the latter two molecules on T cells after activation
Chavin et al., Ann Surg 1993 : Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4 , tumor necrosis factor, and transforming growth factor-beta production
Schwarz et al., Immunology 1995 : Similar to the other cytokines, in peripheral blood mononuclear cells ( PBMC ) from adult donors the highest IL-10 levels were produced in response to CD2 plus CD28 stimulation, within 72-96 hr of stimulation ... Levels of IL-10 in response to CD2 plus CD28 stimulation ( 1.9 +/- 1 ng/ml ) exceeded those in response to SEA ( 0.25 +/- 0.16 ng/ml ), SAC ( 0.43 +/- 0.42 ng/ml ), or LPS ( 0.19 +/- 0.14 ng/ml ) stimulation
Braunstein et al., Gut 1997 : In contrast, it reduces CD2 induced IL-10 production by LPL-T without altering cell growth significantly