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ANGPT1 — SHH

Text-mined interactions from Literome

Lee et al., Int J Mol Med 2007 : Using NIH3T3 embryonic fibroblast cells, we demonstrated that Shh increased the mRNA levels of angiopoietin-1 (Ang-1) , a secreted ligand that regulates endothelial interaction with mural cells ( pericytes and smooth muscle cells ) and promotes blood vessel maturation ... The addition of cyclopamine, an inhibitor of Shh signaling, to NIH3T3 cells, suppressed the regulation of Ang-1 and Ang-2 mRNA levels in the presence of Shh
Nakamura et al., PloS one 2010 (Carcinoma, Pancreatic Ductal...) : In vitro co-culture and matrigel plug assays demonstrated that PDAC cell derived Shh induced Ang-1 and IGF-1 production in BMPCs, resulting in their enhanced migration and capillary morphogenesis activity
Fujii et al., In Vitro Cell Dev Biol Anim 2010 : Shh enhanced Ang-1 expression but did not enhance vascular endothelial growth factor in fibroblasts ... The upregulation of Ang-1 expression by Shh was significantly decreased by fibroblast growth factor-2 (FGF-2), a potent angiogenic factor
Li et al., Mol Neurobiol 2013 (Disease Models, Animal) : The results of silencing Gli-1, or NR2F2, exhibited that exogenous Shh could regulate the expressions of VEGF, Ang-1 , and Ang-2 in astrocytes by activating the NR2F2, but not the Gli-1
Xia et al., PloS one 2013 (Brain Ischemia...) : Shh also increased ZO-1, occludin and Ang-1 expression in BMECs, while cyclopamine and Ang-1 neutralizing antibody inhibited the effects of Shh on the ZO-1 and occludin expression, respectively ... This study suggests that, under ischemic insults, Shh triggers Ang-1 production predominantly in astrocytes, and the secreted Ang-1 acts on BMECs, thereby upregulating ZO-1 and occludin to repair the tight junction and ameliorate the brain edema and BBB leakage