Ludwig et al., J Neurosci 2011
:
Here we demonstrate that in immature hippocampal neurons BDNF robustly induces ERK1/2 ( extracellular signal regulated kinase 1/2 ) -dependent Egr4 expression and rapid Egr4 dependent activation of the KCC2b promoter
Ludwig et al., Neural plasticity 2011
(MAP Kinase Signaling System) :
The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2