Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Parra et al., J Immunol 1995 (Leukemia-Lymphoma, Adult T-Cell) : LFA-3 induced moderate levels of AP-1 , but did not influence the levels of NF-kappa B, while B7 costimulation strongly induced both AP-1 and substantially enhanced NF-kappa B binding proteins ... Our results indicate distinct effects of B7 and LFA-3 costimulation on the activity of AP-1 and NF-kappa B
Wingren et al., Crit Rev Immunol 1995 : LFA-3 costimulation only moderately enhances AP-1 DNA binding activity and does not influence the NF-kappa B activity induced by TCR engagement, whereas B7 costimulation induces large amounts of NF-kappa B and AP-1 activity in T helper cells
Parra et al., Mol Cell Biol 1997 : Both LFA-3 costimulation and B7-1 costimulation induced the AP-1 and NF-kappaB nuclear factors