Gene interactions and pathways from curated databases and text-mining

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CCNB3 — CDK1

Pathways - manually collected, often from reviews:

  • KEGG Cell cycle: Complex of CCNB1-CCNB2-CCNB3-CDK1 → PLK1 (protein-protein, phosphorylation)
  • KEGG Cell cycle: Complex of 14 proteins → Complex of CCNB1-CCNB2-CCNB3-CDK1 (protein-protein, inhibition)
  • KEGG p53 signaling pathway: SFN → Complex of CCNB1-CCNB2-CCNB3-CDK1 (protein-protein, inhibition)
  • KEGG p53 signaling pathway: GADD45A/GADD45B/GADD45G → Complex of CCNB1-CCNB2-CCNB3-CDK1 (protein-protein, inhibition)
  • WikiPathways miRNA Regulation of DNA Damage Response: Complex of CCNB1-CCNB3-CCNB2 → CDK1 (activation)
  • WikiPathways DNA Damage Response: Complex of CCNB1-CCNB3-CCNB2 → CDK1 (activation)

Text-mined interactions from Literome

Borgne et al., J Biol Chem 1999 : We demonstrate that Cdc2 itself is the cyclin B kinase ; cyclin B phosphorylation requires Cdc2 activity both in vivo ( sensitivity to vitamin K3, a Cdc25 inhibitor ) and in vitro ( copurification with Cdc2-cyclin B, requirement of Cdc2 dephosphorylation, and sensitivity to chemical inhibitors of cyclin dependent kinases )
Li et al., Cell Signal 2006 : Activation of cdk1 : : cyclinB1 was coincident with I-2 phosphorylation, but neither MAPK nor GSK3 were phosphorylated at this time, so we concluded that in living cells only cdk1 : : cyclinB1 phosphorylated the PXTP site in I-2