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CD40 — VEGFA

Text-mined interactions from Literome

Cho et al., J Immunol 2000 (Arthritis, Rheumatoid) : Collectively, these results suggest that the interaction between CD40 on synovial fibroblasts and CD40L expressed on activated T lymphocytes may be directly involved in the neovascularization in rheumatoid synovitis by enhancing the production of VEGF
Tai et al., Blood 2002 (Multiple Myeloma...) : CD40 activation induces p53 dependent vascular endothelial growth factor secretion in human multiple myeloma cells ... Transduction of MM cells with a luciferase reporter under the control of a human VEGF promoter further indicated that CD40 induced VEGF expression was mediated through a transcriptional control mechanism ... Finally, adenovirus mediated wild-type p53 overexpression down-regulated CD40 induced VEGF expression and transmigration in MM cells expressing mutant p53 ... These studies demonstrate that CD40 induces VEGF secretion and MM cell migration, suggesting a role for CD40 in regulating MM homing and angiogenesis
Lapchak et al., American journal of physiology. Renal physiology 2004 : CD40 induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island
Flaxenburg et al., J Immunol 2004 : In this study, we have investigated the function of the Ras signaling pathway ( s ) for CD40 induced overexpression of VEGF ... Following transfection, ligation of CD40 with soluble CD40 ligand resulted in a significant increase in VEGF transcriptional activation, and the inhibitory mutant of Ras blocked this CD40 induced VEGF overexpression ... Using EMSA and Western blot analysis, we demonstrated that CD40 dependent binding of nuclear protein ( s ) to the VEGF promoter and CD40 induced VEGF protein expression in EC were also inhibited by the Ras mutant ... Also, wortmanin and a dominant-inhibitory mutant of PI3K inhibited CD40 induced overexpression of VEGF ... Together these findings demonstrate that both Ras and PI3K are intermediaries in CD40 induced regulation of VEGF in EC
Cao et al., Oral Oncol 2005 (Head and Neck Neoplasms...) : CD40 ligation specifically increased the secretion of IL-8, VEGF and PGE ( 2 ) but not IL-6, IL-10, FasL, GM-CSF, or TGFalpha
Danese et al., Gut 2007 (Colitis...) : Engagement of CD40 on HIFs promoted the release of vascular endothelial growth factor ( VEGF ), interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Futagami et al., Prostaglandins Leukot Essent Fatty Acids 2008 (Stomach Neoplasms) : The aim of this study was to examine the effect of MCP-1/CCR2 and CD40-CD40L interaction on COX-2 and VEGF expression in endothelial cells