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EPHA3 — VEGFA

Text-mined interactions from Literome

Chau et al., Oncogene 2002 : Using Northern and Western analyses, transient transfections, and pharmacological agents, we demonstrate that Etk activation alone is sufficient to transcriptionally induce VEGF expression, independent of the previously identified hypoxia response element ( HRE ), in both Pa-4 epithelial and TR-BBB endothelial cells under normoxia ... Taken together, these results indicate that VEGF is both an Etk downstream target gene and an Etk upstream activator , constituting a reciprocal Etk-VEGF autoregulatory loop
Chau et al., Am J Physiol Cell Physiol 2005 (Anoxia...) : Etk/Bmx mediates expression of stress induced adaptive genes VEGF , PAI-1, and iNOS via multiple signaling cascades in different cell systems ... We recently showed that Etk/Bmx , a member of the Tec family of nonreceptor protein tyrosine kinases, promotes tight junction formation during chronic hypoxic exposure and augments normoxic VEGF expression via a feedforward mechanism ... Northern blot analyses confirmed that Etk activation led to induction of steady-state mRNA levels of endogenous VEGF and plasminogen activator inhibitor (PAI)-1, a hallmark of hypoxia mediated gene regulation
Liu et al., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013 (Carcinoma, Squamous Cell...) : [ EphA2 mediated vascular endothelial growth factor expression via the p38 MAPK signaling pathway in squamous cell carcinoma of the head and neck ]