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IL6 — NFKBIA

Text-mined interactions from Literome

Alpert et al., J Biol Chem 1999 : In addition, sorbitol and H ( 2 ) O ( 2 ) blocked TNF induced but not interleukin-1 induced IkappaBalpha phosphorylation, whereas arsenite inhibited IkappaBalpha phosphorylation induced by TNF and interleukin-1
Fiebich et al., Neuropharmacology 1999 (Alzheimer Disease) : The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha
Luckey et al., J Pharmacol Exp Ther 2002 (Adenoviridae Infections) : In conclusion, these data suggest that 4-HNE inhibits IL-6 production in rat Kupffer cells by preventing activation of the NF-kappaB pathway and suppressing IkappaBalpha phosphorylation
Soloff et al., Mol Hum Reprod 2004 : We were unable to detect any significant differences between primary and immortalized cells in signal pathways such as epidermal growth factor stimulated epidermal growth factor receptor phosphorylation, insulin stimulated Akt phosphorylation, oxytocin and lysophosphatidic acid stimulated extracellular signal regulated kinase 1 and 2 phosphorylation, myosin light chain phosphorylation, and interleukin-1 induction of IkappaBalpha degradation
Zhu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005 : The results indicated that deltaN IkappaBalpha may inhibit the activation of NF-kappaB and reduce the release of TNF-alpha and IL-6 , suggesting the recombinant deltaN IkappaBalpha adenovirus may be used for anti-inflammatory therapy
Wong et al., Am J Respir Cell Mol Biol 2005 : IL-25 could also activate the JNK, p38 MAPK, and NF-kappaB activities of eosinophils, while inhibitor of IkappaB-alpha phosphorylation ( BAY11-7082 ), JNK ( SP600125 ), and p38 MAPK ( SB203580 ) could suppress the release of IL-8, MIP-1alpha, MCP-1, and IL-6
Piazza et al., Blood 2006 (Multiple Myeloma) : CK2 inhibition also resulted in impaired IL-6 dependent STAT3 activation and in decreased basal and TNF-alpha dependent I kappaB alpha degradation and NF-kappaB-driven transcription
Chen et al., J Immunol 2006 : Peptidoglycan induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase , and NF-kappa B
Peng et al., Exp Cell Res 2007 (Inflammation...) : We have further identified that interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) from PMN-melanoma co-cultures synergistically contribute to IkappaB-alpha degradation and IL-8 synthesis in PMNs. Taken together, these findings show that melanoma cells induce PMNs to secrete IL-8 through activation of NF-kappaB and suggest a model in which this interaction promotes a microenvironment that is favorable for metastasis
Newton et al., J Pharmacol Exp Ther 2007 (Pulmonary Disease, Chronic Obstructive) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF) alpha increased phosphorylation of IkappaBalpha , and this was followed by loss of IkappaBalpha, induction of NF-kappaB DNA binding, and the induction of NF-kappaB dependent transcription
Tang et al., J Immunol 2007 : Leptin mediated IL-6 production was attenuated by OBRl receptor antisense oligonucleotide, PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Jiang et al., Eur J Haematol 2009 (Multiple Myeloma) : We also found that IFN-gamma and IL-6 can induce BLyS expression on MM cells, while after the treatment of BAY11-7082, an IkB-alpha phosphorylation inhibitor, IFN-gamma induced up regulation of BLyS was completely inhibited, suggesting that nuclear factor kappaB (NF-kappaB) might be involved in the mechanism of the regulation of BLyS levels in response to cytokines
Sierra et al., Microb Pathog 2010 (Gram-Negative Bacterial Infections) : Further, AexU prevented phosphorylation of c-Jun, JNK and IkappaBalpha and inhibited IL-6 and IL-8 secretion from HeLa cells
Ghosh et al., J Immunol 2010 : Surprisingly, however, whereas mRNA expression and cellular release of TNF-alpha, the beta form of pro-IL-1 ( IL-1beta ), and IL-6 were inhibited by the leptomycin B-induced nuclear IkappaBalpha , IL-8 mRNA expression and cellular release were not significantly affected
Keller et al., J Biol Chem 1996 (Prostatic Neoplasms) : Finally, we confirmed that IkappaBalpha inhibits NFkappaB mediated activation of the interleukin-6 promoter
Sun et al., Biochem Biophys Res Commun 1998 (Osteoporosis, Postmenopausal) : Here, we sought to determine whether E2 regulates IL-6 gene expression by modulating the levels of I kappa B alpha