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CDKN1A — HRAS

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → HRAS (increases, CDKN1A Activity) Yoo et al., Int J Oncol 2006*
  Evidence: H-RasG12V expression down-regulated p27Kip1 expression, and that RASSF1A co-transfected with H-RasG12V recovered p27Kip1 expression that had been down-regulated by H-RasG12V expression. Similarly, p21WAF1/CIP1 was induced by H-RasG12V expression and RASSF1A co-transfected with H-RasG12V inhibited p21WAF1/CIP1 induction.
• OpenBEL Selventa BEL large corpus: CDKN1A → HRAS (increases)
  Evidence: We found that Ras activation resulted in elevated expression of p53 (2-fold, P0.05) and p21 (17- fold, P0.01) as well as p16 (5-fold, P0.01; Figure 1B and Data Supplement Figure II), which suggests that Ras-induced growth arrest is different from quiescence, because neither p53 nor p16 accumulates during quiescence.

Text-mined interactions from Literome

Gartel et al., Oncogene 2000 : Here we show that activated V12-H-Ras can induce the p21 promoter through the same region of the p21 promoter by a p53 independent mechanism in NIH3T3 cells
Bacciocchi et al., Anticancer Res 1992 (Chromosome Aberrations...) : Enhanced expression of Ha-ras and c-myc genes resulted from high p-21 and p-62 levels
McKay et al., EMBO J 1986 (Cell Transformation, Neoplastic) : T15 cells have been used to demonstrate that : ( i ) a 20- to 50-fold over-expression of normal p21ras is required for complete cellular transformation, ( ii ) p21N-ras expression induces DNA synthesis and the effect can be amplified by epidermal growth factor, ( iii ) moderate increases in normal p21ras expression can influence cell behaviour
Tsunematsu et al., Biochem Mol Biol Int 1997 (Carcinoma, Hepatocellular...) : However, neither the 10-100 times higher ras p21 expression required for murine fibroblast transformation by itself nor the mutational activation of the H-ras gene was observed in carbon tetrachloride induced hepatic tumors