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E2F1 — POLDIP2
Text-mined interactions from Literome
Hershko et al., J Biol Chem 2006
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We show here that E2F1 modulates the activity of the p38 MAPK pathway via
E2F1 induced transient up-regulation of
p38 MAPK phosphorylation
de Olano et al., Mol Cancer Res 2012
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Consistently, studies using pharmacologic inhibitors, siRNA knockdown, and knockout mouse embryonic fibroblasts (MEF) revealed that
p38 mediates the
E2F1 induction by epirubicin and that the induction of E2F1 by p38 is, in turn, mediated through its downstream kinase MK2 [ mitogen activated protein kinase ( MAPK) activated protein kinase 2 ; MAPKAPK2 ]