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ARF6 — VEGFA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of ARF6-RAC1
→
VEGFA
(increases)
Evidence: In ECs, VEGF stimulates ARF6 association with Rac1, which is cotemporaneous with Rac1 activation.
Text-mined interactions from Literome
Martin et al., Invest Ophthalmol Vis Sci 2004
(Eye Abnormalities...) :
In the HVS,
Arf expression in perivascular cells may block their accumulation or
repress Vegf expression to promote HVS involution and prevent PHPV
Ikeda et al., Circ Res 2005
(Ischemia) :
Thus,
ARF6 is
involved in the temporal-spatial organization of caveolae/lipid rafts- and ROS dependent
VEGF signaling in ECs as well as in angiogenesis in vivo