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LCK — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Manna et al., J Biol Chem 2000
:
Protein tyrosine kinase
p56lck is
required for ceramide induced but not tumor necrosis factor induced activation of
NF-kappa B , AP-1, JNK, and apoptosis
Manna et al., J Immunol 2000
:
Overall, our results demonstrate that
p56lck plays a critical role in the activation of
NF-kappa B , AP-1, JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of these responses by TNF
Mahabeleshwar et al., J Biol Chem 2003
(Anoxia...) :
The molecular mechanism ( s ) by which hypoxia/reoxygenation ( H/R ) regulates
p56lck dependent
activation of
NFkappaB through tyrosine phosphorylation of IkappaBalpha and modulates the expression of downstream genes that are involved in cell migration in human breast cancer cells are not well defined ... In this paper, we investigated the
involvement of protein-tyrosine kinase
p56lck in the redox regulated activation of
NFkappaB following H/R in highly invasive ( MDA-MB-231 ) and low invasive ( MCF-7 ) breast cancer cells ... Transfection of these cells with wild type Lck but not with mutant Lck F394 followed by H/R induces the tyrosine phosphorylation of inhibitor of nuclear factor kappaB ( IkappaBalpha ) and transcriptional activation of
NFkappaB , and these are
inhibited by
Lck inhibitors ... To our knowledge, this is the first report that
p56lck in presence of H/R
regulates NFkappaB activation, uPA secretion, and cell motility through tyrosine phosphorylation of IkappaBalpha and further demonstrates an important redox regulated pathway for NFkappaB activation following H/R injury that is independent of IkappaB kinase/IkappaBalpha mediated signaling pathways