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ATF4 — PTH

Text-mined interactions from Literome

Yu et al., Endocrinology 2008 : Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts : requirement for osteocalcin gene expression ... In the present study, we examined effects of PTH on ATF4 expression and activity as well as the requirement for ATF4 in the regulation of Ocn by PTH ... Collectively, these studies for the first time demonstrate that PTH increases ATF4 expression and activity and that ATF4 is required for PTH induction of Ocn expression in osteoblasts
Fei et al., Biochem Biophys Res Commun 2011 : In vitro data showed that PTH induced a significant increase in ATF4 mRNA expression as early as 15 min in Fgf2 ( +/+ ) primary bone marrow stromal cells ( BMSCs ) but not in Fgf2 ( -/- ) BMSCs ... In summary, reduced ATF4 expression may result in decreased osteoblast differentiation, and possibly contribute to the impaired stimulation of PTH on bone formation in Fgf2 ( -/- ) mice