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AKT1 — FGFR1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AKT1 → FGFR1 (increases, FGFR1 Activity, AKT1 Activity)
  Evidence: PIP3 has been described as a downstream component of a wide range of receptors, including the c-Met receptor [5], the epidermal growth factor receptor family [6], fibroblast growth factor receptor [7], insulin growth factor receptor [8] and platelet-derived growth factor receptor

Text-mined interactions from Literome

Dong et al., Blood 2007 (Cell Transformation, Neoplastic...) : We found that ZNF198-FGFR1 activated both the AKT and mitogen activated protein kinase ( MAPK ) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT target FOXO3a at T32 and BAD at S112, respectively
Mori et al., J Biol Chem 2008 : Nevertheless, R50E induced phosphorylation of FGFR1 and FRS2alpha and activation of AKT and ERK1/2
Huang et al., Mol Carcinog 2009 (Liver Neoplasms, Experimental) : Analysis of activation of Erk, JNK, and PI3K related AKT signaling pathways indicated that in contrast to FGFR1, FGFR4 failed to sustain Erk activation and did not activate AKT
Shiang et al., Breast Cancer Res Treat 2010 (Breast Neoplasms) : In cells with amplified FGFR-1 , brivanib decreased receptor autophosphorylation, inhibited bFGF induced tyrosine kinase activity, and reduced phosphorylation of ERK and AKT
Zou et al., J Biol Chem 2012 : Whereas FGF ligand induced phosphorylation of FGFR1 preferentially activates ERK, FN-induced phosphorylation of FGFR1 preferentially activates AKT , indicating differential downstream signaling of FGFR1 in response to alternate stimuli ... Mutation analysis of known tyrosine residues of FGFR1 reveals that tyrosine 653/654 and 766 residues are required for FN-FGFR1 activation of AKT and chemotaxis
Mavila et al., PloS one 2012 (Liver Neoplasms) : FGF Receptor ( R ) activation resulted in the downstream activation of MAPK, PI3K-AKT , and ß-catenin pathways, as well as cellular proliferation
Kenerson et al., Gastroenterology 2013 (Carcinoma, Hepatocellular...) : Inhibition of fibroblast growth factor receptor 1 in Tsc1-null mice suppressed Akt and mitogen activated protein kinase activities in tumor cells