◀ Back to EGFR

EGFR — TWIST1

Text-mined interactions from Literome

Lo et al., Cancer Res 2007 (Breast Neoplasms...) : TWIST expression is suppressed by EGFR and Janus activated kinase ( JAK ) /signal transducer and activator of transcription 3 ( STAT3 ) inhibitors, but not significantly by those targeting phosphoinositide-3 kinase and MEK/ERK
Li et al., Cell Death Differ 2011 (Breast Neoplasms) : With the use of chromatin immunoprecipitation-seq analysis, we demonstrated that miR-448 suppression induces EMT by directly targeting special AT-rich sequence binding protein-1 ( SATB1 ) mRNA, leading to elevated levels of amphiregulin and thereby, increasing epidermal growth factor receptor (EGFR) mediated Twist1 expression, as well as nuclear factor ?B ( NF-?B ) activation
Burns et al., Mol Cancer Res 2013 : In xenograft models, silencing of TWIST1 resulted in significant growth inhibition of KRAS-mutant, EGFR-mutant , and c-Met amplified NSCLCs. Remarkably, inducible silencing of TWIST1 resulted in significant growth inhibition of established KRAS-mutant tumors