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KLF4 — SP1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
KLF4
—
SP1
(direct interaction, pull down)
Zhang et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
KLF4
—
SP1
(colocalization, imaging technique)
Zhang et al., Arterioscler Thromb Vasc Biol 2012*
-
IRef Biogrid Interaction:
KLF4
—
SP1
(physical association, affinity chromatography technology)
Zhang et al., Arterioscler Thromb Vasc Biol 2012*
-
IRef Hprd Interaction:
KLF4
—
SP1
(in vitro)
Higaki et al., Nucleic Acids Res 2002*, Zhang et al., J Biol Chem 1998*
-
IRef Ophid Interaction:
KLF4
—
SP1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kanai et al., Clin Cancer Res 2006
(Adenocarcinoma...) :
Enforced
KLF4 expression
repressed Sp1 expression at the promoter activity, mRNA, and protein levels
Deaton et al., Am J Physiol Heart Circ Physiol 2009
(Disease Models, Animal...) :
Sp1 dependent activation of
KLF4 is required for PDGF-BB induced phenotypic modulation of smooth muscle ... The results demonstrated that the transcription factor
stimulating protein-1 (Sp1) regulated the expression of
KLF4 in SMCs ... In addition, overexpression of
Sp1 alone was
sufficient to increase the activity of the
KLF4 promoter ... Taken together, the results suggest a novel
role for
Sp1 in increasing the expression of
KLF4 in phenotypically modulated SMCs
Sharma et al., Gene 2013
(Cell Transformation, Neoplastic...) :
This over expressed miR-2909 was found to regulate CCND1 ( Cyclin D1 ) gene expression, within these cells by
inducing splice switching of tumor suppresser CYLD ( Cylindromatosis ) gene as well as modulation of
SP1 ( Specificity Protein 1 ) activity through the repression of
KLF4 ( Kruppel-like factor4 ) expression at the translational level