Harris et al., Cancer Res 2004
(Adenocarcinoma...) :
It is proposed that gastrin acting in an autocrine and endocrine manner via a CCK-2R isoform may activate PKB/Akt and that with expression of gastrin and CCK-2R isoforms increasing in BM samples, gastrin may aid progression of BM through amplification of antiapoptotic pathways
Subramaniam et al., Gastroenterology 2008
(Adenocarcinoma...) :
Gastrin mediated Akt activation was observed to be downstream of p38
Berna et al., J Biol Chem 2010
:
Akt activation by CCK and gastrin could be inhibited by the PI3K inhibitor wortmannin
Min et al., J Pineal Res 2012
:
Inhibitory effects of melatonin on the lipopolysaccharide induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt induced NF-?B and STAT/GAS activity