Gene interactions and pathways from curated databases and text-mining

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MUC1 — NRG1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of JUP-MUC1 → NRG1 (increases) Li et al., Mol Cancer Res 2003*
    Evidence: The importance of the MUC1-ErbB2 interaction is supported by the demonstration that HRG induces binding of MUC1 and gamma-catenin and targeting of the MUC1-gamma-catenin complex to the nucleolus. # gamma catenin = JUP # HRG = NRG1
  • OpenBEL Selventa BEL large corpus: MUC1 → NRG1 (increases, NRG1 Translocation) Li et al., Mol Cancer Res 2003*
    Evidence: mutation of a RRK motif in the MUC1 cytoplasmic domain abrogates HRG-induced nucleolar localization of MUC1 and gamma-catenin.