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EPHB2 — MSH6
Text-mined interactions from Literome
Chai et al., Peptides 2006
(MAP Kinase Signaling System) :
NDP-MSH stimulated
ERK1/2 phosphorylation in a dose dependent manner
Chai et al., Regul Pept 2007
:
NDP-MSH induced
ERK1/2 phosphorylation was sensitive to pertussis toxin and the PI3K inhibitor, wortmannin ... Rp-cAMPS, BAPTA-AM and Myr-PKC did not inhibit the
NDP-MSH induced
ERK1/2 phosphorylation
Rodrigues et al., Mol Cell Endocrinol 2009
(MAP Kinase Signaling System) :
Moreover, in cells stably expressing MC5R-GFP,
alpha-MSH promoted
ERK1/2 phosphorylation in a dose dependent manner ( EC50=7.3 nM ) with the maximal effect occurring after 5 min of agonist incubation ... However,
alpha-MSH induced
ERK1/2 activation is abolished by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002