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IL4 — IRF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Coccia et al., J Biol Chem 1999
:
No significant differences of IRF-1 mRNA expression were found in established Th1 and Th2 cells ; however,
interleukin 12 (IL-12)
induced a strong up-regulation of
IRF-1 transcripts in Th1 but not in Th2 cells
Ackermann et al., J Immunol 1999
:
Both IFN-gamma and
IL-4 increased expression of the inducible transcription factor
IFN regulatory factor-1 (IRF-1) , but levels of IRF-1 only weakly correlated with levels of pIgR mRNA, suggesting that additional transcription factors are required
Galon et al., J Immunol 1999
:
In contrast to IL-12, no up-regulation of
IRF-1 was found in IL-4 stimulated cells, and
IL-4 did not
block IL-12 dependent up-regulation of IRF-1
Yu et al., Exp Mol Med 2004
(Carcinoma, Renal Cell...) :
In summary, our study indicated that p21WAF1 and
IRF-1 mediate the growth inhibitory effect of
IL-4 in human RCC cells
Ohmori et al., J Immunol 1997
:
These observations suggest that
IL-4 may
suppress IFN-gamma stimulated transcription of the
IRF-1 gene by activation of STAT6, which can compete with STAT1 for occupancy of the IRF-1 SBE when STAT1 levels are low