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GFAP — TGFB1
Text-mined interactions from Literome
Krohn et al., J Neurochem 1999
:
Glial fibrillary acidic protein transcription
responses to
transforming growth factor-beta1 and interleukin-1beta are mediated by a nuclear factor-1-like site in the near-upstream promoter ... Mutagenesis ( 3-bp exchanges ) in -70 to -68 bp blocked the
induction of
GFAP by
TGF-beta1 and the repression by IL-1beta
Sousa et al., Eur J Neurosci 2004
:
We demonstrated that cerebral cortex neurons activate the
GFAP gene promoter,
inducing transforming growth factor-beta 1 ( TGF-beta 1 ) secretion by astrocytes
Sakai et al., Proc Natl Acad Sci U S A 1990
:
Serum and
transforming growth factor beta regulate
glial fibrillary acidic protein in serum-free derived mouse embryo cells
Romão et al., J Neurochem 2008
:
Surprisingly, these inhibitors also abrogated TGF-beta1 direct action on GFAP gene although they did not inhibit Smad-2 phosphorylation, suggesting that
TGF-beta1 induced
GFAP gene activation might involve cooperation between the canonical and non-canonical TGF-beta pathways
Nishiyama et al., Neurosci Lett 1993
:
The cell line expresses
glial fibrillary acidic protein (GFAP) in
response to
transforming growth factor beta or serum and cells with similar properties can be isolated directly from brain
Reilly et al., Glia 1998
:
Cycloheximide did not block the effects of TGF-beta1 or FGF-2 on GFAP mRNA levels, but blocked the inhibitory effects of FGF-2 on the
TGF-beta1 mediated increase in
GFAP expression