Gene interactions and pathways from curated databases and text-mining

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GFAP — TGFB1

Text-mined interactions from Literome

Krohn et al., J Neurochem 1999 : Glial fibrillary acidic protein transcription responses to transforming growth factor-beta1 and interleukin-1beta are mediated by a nuclear factor-1-like site in the near-upstream promoter ... Mutagenesis ( 3-bp exchanges ) in -70 to -68 bp blocked the induction of GFAP by TGF-beta1 and the repression by IL-1beta
Sousa et al., Eur J Neurosci 2004 : We demonstrated that cerebral cortex neurons activate the GFAP gene promoter, inducing transforming growth factor-beta 1 ( TGF-beta 1 ) secretion by astrocytes
Sakai et al., Proc Natl Acad Sci U S A 1990 : Serum and transforming growth factor beta regulate glial fibrillary acidic protein in serum-free derived mouse embryo cells
Romão et al., J Neurochem 2008 : Surprisingly, these inhibitors also abrogated TGF-beta1 direct action on GFAP gene although they did not inhibit Smad-2 phosphorylation, suggesting that TGF-beta1 induced GFAP gene activation might involve cooperation between the canonical and non-canonical TGF-beta pathways
Nishiyama et al., Neurosci Lett 1993 : The cell line expresses glial fibrillary acidic protein (GFAP) in response to transforming growth factor beta or serum and cells with similar properties can be isolated directly from brain
Reilly et al., Glia 1998 : Cycloheximide did not block the effects of TGF-beta1 or FGF-2 on GFAP mRNA levels, but blocked the inhibitory effects of FGF-2 on the TGF-beta1 mediated increase in GFAP expression