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TGFB1 — TGFB2

Pathways - manually collected, often from reviews:

• BioCarta tgf beta signaling pathway: TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1) → TGF-beta (TGFB1/TGFB2/TGFB3) (modification, collaborate)
  
• BioCarta ctcf: first multivalent nuclear factor: TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) → TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) (modification, collaborate)
  
• BioCarta nfkb activation by nontypeable hemophilus influenzae: TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) → TGF-beta (TGFB1/TGFB2/TGFB3) (modification, collaborate)
  
• BioCarta ctcf: first multivalent nuclear factor: TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1) → TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) (modification, collaborate)
  
• BioCarta alk in cardiac myocytes: TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) → TGF-beta (TGFB1/TGFB2/TGFB3) (modification, collaborate)
  
• BioCarta ctcf: first multivalent nuclear factor: TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1) → TGF-beta (TGFB1/TGFB2/TGFB3) (modification, collaborate)
  
• BioCarta tgf beta signaling pathway: TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) → TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) (modification, collaborate)
  
• BioCarta tgf beta signaling pathway: TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1) → TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1) (modification, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TGFB1 — TGFB2 (direct interaction, two hybrid) Perlman et al., Nat Cell Biol 2001*
• IRef Hprd Interaction: TGFB1 — TGFB2 (in vivo) Rotzer et al., EMBO J 2001*
• IRef Intact Interaction: Complex of TGFB2-TGFB1-APP (association, competition binding) Bodmer et al., Biochem Biophys Res Commun 1990*
• IRef Ophid Interaction: TGFB1 — TGFB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tardif et al., Arthritis Rheum 1999 (Osteoarthritis) : Indeed, TGFbeta2 did not induce collagenase 1 synthesis, whereas TGFbeta1 stimulated it
Raghow et al., J Urol 1999 : With declining androgen levels TGF-alpha, TGF-beta2 and TGF-beta3 remained unchanged but TGF-beta1 increased in the mesenchyme with no change in the tested peptide growth factor levels in the epithelium
Dahiya et al., Int J Impot Res 1999 (Erectile Dysfunction) : The results of these experiments suggest that : ( 1 ) young and old rat penile tissues expressed mRNA transcripts for TGF alpha, TGF beta 1, TGF beta 2, TGF beta 3, IGF and NGF ; ( 2 ) TGF beta 1 gene expression was significantly increased in old rat penile tissues as compared to young ; ( 3 ) mRNA transcripts for NGF and TGF beta 3 were significantly lower in old rat penile tissues as compared to young ; and ( 4 ) TGF alpha, TGF beta 2 and IGF mRNA expression did not change in young and old rat penile tissues
Nilsson et al., Mol Cell Endocrinol 2001 (Ovarian Neoplasms) : Transforming growth factor alpha ( TGFalpha ) stimulated TGFbeta1 expression, TGFbeta1 stimulated TGFbeta2 expression, and follicle stimulating hormone ( FSH ) stimulated TGFbeta3 expression
Quan et al., J Invest Dermatol 2002 : Ultraviolet induction of Smad7 and reduction of transforming growth factor beta2 and transforming growth factor beta type II receptor should diminish transforming growth factor beta signaling, and probably contribute to the decrease of transforming growth factor beta regulated type I and type III procollagen gene expression observed in ultraviolet and solar simulated ultraviolet irradiated human skin in vivo
Yu et al., Kidney Int 2003 (Fibrosis) : In contrast, TGF-beta2 and -beta3 stimulated TGF-beta1 in all three cell types
Wen et al., Am J Respir Cell Mol Biol 2004 : Exogenous TGF-beta1 and 3, IL-1beta, PDGF, and IL-4 enhanced TGF-beta2 release by HBECs ( P < 0.01 )
del Re et al., J Biol Chem 2004 : In the absence of type III receptor, the transforming growth factor ( TGF ) -beta type II-B receptor requires the type I receptor to bind TGF-beta2
Yue et al., J Cell Physiol 2004 : We have previously demonstrated that activation of the Ras/Mapk pathways is required for transforming growth factor beta ( TGF-beta ) induction of TGF-beta(1) expression
Scaffidi et al., J Biol Chem 2004 : To determine whether alpha ( v ) beta ( 3 ) regulates transforming growth factor beta ( TGFbeta) 1-induced responses , we investigated the interaction between alpha ( v ) beta ( 3 ) and TGFbeta type II receptor ( TGFbetaIIR ) in primary human lung fibroblasts
Harakeh et al., Chem Biol Interact 2004 (Leukemia, T-Cell...) : Interestingly, in three of the four cell lines used, DCQ increased the TGF-beta1 transcript levels and decreased TGF-alpha mRNA, but did not induce changes in TGF-beta2 expression
Norata et al., Circulation 2005 (Inflammation) : Quantitative real-time polymerase chain reaction confirmed that HDL subfraction 3 selectively induces TGF-beta2 mRNA expression and protein release, whereas TGF-beta1 and TGF-beta3 were not affected
Liu et al., Adv Perit Dial 2005 : We investigated the effect of transforming growthfactor beta ( TGFbeta1 ) short hairpin RNA ( shRNA ) mediated by pcDU6 plasmid on TGFbeta1 expression in human peritoneal mesothelial cells ( HPMCs ) and compared that effect with the effect of antisense TGFbeta1 RNA
Hassoba et al., Egypt J Immunol 2005 (Penile Induration) : TGF-beta1 protein expression was detected in 30 patients ( 85.7 % ), while only 8 ( 22.8 % ) and 6 ( 17.1 % ) patients showed TGF-beta2 and TGF-beta3 protein expression, respectively
Nagineni et al., J Cell Physiol 2007 : The TGF-beta1 and TGF-beta2 secretion was induced by TGF-beta2 and TGF-beta1 , respectively ... JAK inhibitor selectively inhibited IFN-gamma induced TGF-beta1 secretion and mRNA levels while reversing the inhibitory effects of IFN-gamma on TGF-beta2
Segarini et al., J Biol Chem 1992 : Two novel patterns of transforming growth factor beta ( TGF-beta ) binding to cell surface proteins are dependent upon the binding of TGF-beta 1 and indicate a mechanism of positive cooperativity ... The level of TGF-beta 1 binding to this protein is dependent on the presence of TGF-beta 2
Hatsushika et al., Clin Exp Allergy 2007 (Asthma...) : TGF-beta(2) expression was observed in both the normal and asthmatic bronchial epithelium, and both real-time PCR and an ELISA showed a significant basal and TGF-beta(1) induced TGF-beta(2) expression in the bronchial epithelial cell line BEAS2B
Dai et al., Am J Pathol 2007 : Furthermore, transforming growth factor beta-1 ( TGF-beta1 ) and TGF-beta1-receptor II expression were decreased in UVB irradiated biopsies, and TGF-beta1 strongly induced HAS1 and HAS2 expression in cultured dermal fibroblasts
Peng et al., Toxicology 2008 (Disease Models, Animal...) : In tumors arising in RB-positive livers, Cdkn2d and Tgfb1 were repressed and Cdkn2c, Tgfb2 , Tgfb3 and Pai1 were induced , whereas in RB-negative tumors, only Cdkn2c and Tgfb3 were induced
Merwin et al., Am J Pathol 1991 : In contrast, BASMC migration was enhanced by TGF-beta 1 and was not affected by TGF-beta 2
Zhou et al., Oncol Rep 2008 (Colorectal Neoplasms...) : Soluble transforming growth factor beta type II receptor attenuates TGF-beta1 activity in human colorectal cancer LoVo cells
Bottoms et al., PloS one 2010 (Asthma...) : Anti-TGF-beta(1) and anti-TGF-beta(2) inhibited ovalbumin induced sub-epithelial collagen deposition but anti-TGF-beta(1) also specifically regulated airway and fibroblast decorin deposition by TGF-beta(1)
Lian et al., Coron Artery Dis 2010 (Disease Models, Animal...) : Soluble transforming growth factor-beta1 receptor II might inhibit transforming growth factor-beta induced myofibroblast differentiation and improve ischemic cardiac function after myocardial infarction in rats
Vincze et al., J Comp Neurol 2010 (Brain Ischemia...) : TGF-beta1 was induced in the penumbral region of cortex and striatum, whereas TGF-beta2 and -beta3 were induced in different layers of the ipsilateral cortex
Wakefield et al., J Cell Sci Suppl 1990 : We have shown that anti-estrogens induce the production of TGF-beta 1 in mammary carcinoma cells and fetal fibroblasts, whereas retinoic acid specifically induces TGF-beta 2 in primary epidermal keratinocytes
Bascom et al., Mol Cell Biol 1989 : Regulation of transforming growth factor beta 1 ( TGF beta 1 ), TGF beta 2, and TGF beta 3 mRNAs in murine fibroblasts and keratinocytes by TGF beta 1 and TGF beta 2 was studied ... Neither TGF beta 2 nor TGF beta 3 mRNA, however, was significantly induced, but both were apparently down regulated at later times by TGF beta 1 ... Autoinduction of TGF beta 2 mRNA occurred rapidly with maximal induction at 1 to 3 h, enhanced TGF beta 3 mRNA levels were observed after 3 h, and increased expression of TGF beta 1 occurred later, with maximal mRNA levels obtained after 12 to 24 h. Nuclear run-on analyses indicated that TGF beta 2 regulation of TGF beta 2 and TGF beta 3 mRNA levels is transcriptional, while TGF beta 2 induction of TGF beta 1 expression most likely involves both transcriptional and posttranscriptional controls
Daniels et al., Biotherapy 1989 : Of these, TGF-beta 2 was more active than TGF-beta 1 in fourteen ; and TGF-beta 1 was more active than TGF-beta 2 in five
Roelen et al., Dev Biol 1994 : TGF-beta 1 and TGF-beta 2 transcripts were detected before gastrulation at 6.5 dpc only in the visceral embryonic endoderm, whereas during gastrulation, at 7.5 dpc TGF-beta 1 and TGF-beta 2 mRNA was detected in all three germ layers
Lin et al., J Biol Chem 1995 : In contrast, 125I-TGF-beta 2 can not bind and be chemically cross linked to the soluble type II receptor, nor does as much as a 125-fold excess of unlabeled TGF-beta 2 inhibit the binding of 125I-TGF-beta 1 to the soluble receptor
Maeda et al., Clin Exp Immunol 1994 (Carcinoma, Small Cell...) : Although TGF-beta 1-like activity could be detected in all cases, TGF-beta 2-like activities were detected in five of seven in MESO and in a few cases with primary lung cancer
Taipale et al., J Cell Biol 1994 (Fibrosarcoma) : The role of latent transforming growth factor-beta ( TGF-beta ) binding protein ( LTBP ) in the association of TGF-beta 1 to the extracellular matrix of cultured fibroblasts and HT-1080 fibrosarcoma cells was studied by immunochemical methods
Waltenberger et al., Am J Pathol 1993 (Carcinoid Heart Disease...) : TGF-beta 1 and TGF-beta 3 were detected in the fibroblasts of all plaques analyzed, whereas TGF-beta 2 was only rarely expressed
Knabbe et al., Ann N Y Acad Sci 1996 (Breast Neoplasms) : The influence of antiestrogens on the secretion of transforming growth factor beta ( TGF beta ) proteins that have an autoinhibitory potential for human cancer cells was studied in the estrogen-responsive human breast cancer cell line, MCF-7 : Antiestrogens induce the secretion of TGF beta-1 via a nontranscriptional pathway ; TGF beta-1 itself induces TGF beta-2 by a direct transcriptional mechanism ; and TGF beta-2 is a marker of antiestrogen action
Jakowlew et al., Growth Factors 1997 (Carcinoma, Non-Small-Cell Lung...) : The effects of these agents on expression of the mRNAs for TGF-beta 2 and TGF-beta 3 were more complex ; while TGF-beta 2 and TGF-beta 3 mRNAs increased transiently in response to TGF-beta 1 in NHBE cells and TGF-beta 3 mRNA increased transiently in some NSCLC cells, expression of these mRNAs decreased in most of these cells in response to PMA with the exception of the carcinoid NCI-H727 where TGF-beta 2 mRNA increased dramatically, TGF-beta 1 and PMA both caused a persistent increase in expression of the mRNAs for both plasminogen activator inhibitor-1 ( PAI-1 ) and plasminogen activator (PA) up to 24 hr in most NSCLC cells, with the increase in PAI-1 mRNA beginning several hours before that of PA mRNA
Kleeff et al., J Biol Chem 1998 (Pancreatic Neoplasms) : Up-regulation of transforming growth factor ( TGF ) -beta receptors by TGF-beta1 in COLO-357 cells
Kim et al., Exp Cell Res 1998 (Prostatic Neoplasms) : The conventional transforming growth factor-beta ( TGF-beta) receptor type I is not required for TGF-beta 1 signaling in a human prostate cancer cell line, LNCaP