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NFKB1 — VAV1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Dienz et al., J Biol Chem 2000
:
PKCtheta induced
NF-kappaB activation was synergistically
augmented by
Vav ... In addition to the synergistic activation cascade,
Vav also
triggered NF-kappaB activity on a separate route ... CD3/CD28 induced activation of
NF-kappaB was
inhibited by dominant negative forms of
Vav or PKCtheta, revealing their essential role in this activation pathway
Marinari et al., Eur J Immunol 2002
:
Finally,
Vav induced
NF-kappaB activation in CD28 costimulated cells was inhibited by dominant negative MEKK ( KM )
Dienz et al., J Immunol 2003
:
In contrast,
Vav1 induced
NF-kappaB activation was normal in SLP-76 ( - ) cells, but absent in PLCgamma1 ( - ) cells
Fernandez-Zapico et al., Cancer Cell 2005
(Adenocarcinoma...) :
Mechanistically, the effects of
Vav1 require its GEF activity and the activation of Rac1, PAK1, and
NF-kappaB and involve cyclin D1 upregulation
Tybulewicz et al., Curr Opin Immunol 2005
:
Vav1 is
required for TCR induced calcium flux, activation of the ERK MAP kinase pathway, activation of the
NF-kappaB transcription factor, inside-out activation of the integrin LFA-1, TCR clustering, and polarisation of the T cell
Oakley et al., J Biol Chem 2009
:
Finally, we demonstrate that
Vav1 , a Rac1 guanine exchange factor and activator of Nox2, is recruited to lipid rafts following IL-1beta stimulation and that it is
required for
NFkappaB activation