◀ Back to VIP
SERPINB3 — VIP
Text-mined interactions from Literome
McEwan et al., Biochim Biophys Acta 1992
:
100 microM DIDS ( 4,4'-diisothiocyanantostilbene-2,2'-disulphonic acid ) also abolished the cell swelling activated increase in SCC ; DIDS is without effect upon the
VIP stimulated
SCC , suggesting distinct Cl- channels are involved in the two responses
Cox et al., Br J Pharmacol 1995
(Adenocarcinoma...) :
2. The
VIP induced increase in basal
short-circuit current (SCC) was attenuated by basolateral application of Som, PYY or NPY, and also by the Y1-receptor agonist [ Leu31,Pro34 ] NPY, as well as pancreatic polypeptide (PP)
Holliday et al., Br J Pharmacol 1996
:
In contrast, basolateral additions of PYY reduced both basal and
VIP stimulated
SCC in all three Y1 clones ... In the Y1-7 clone, BIBP 3226 fully inhibited the reductions in
VIP stimulated
SCC induced by 30 nM PYY, with an IC50 of 27.2 nM and 30 nM BIBP 3226 caused a parallel rightward shift on the PYY concentration-response curve, with an approximate pKB of 8.0
Holliday et al., Naunyn Schmiedebergs Arch Pharmacol 1997
(Adenocarcinoma...) :
The alpha 2-adrenoceptor agonist clonidine also attenuated
VIP stimulated
SCC ( EC50342 nM ) through the alpha 2A receptor subtype, since clonidine responses were inhibited by yohimbine and rauwolscine but not altered by previous addition of prazosin
Thorbøll et al., Regul Pept 1998
:
VIP caused a TTX-insensitive and a concentration dependent increase in
SCC