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BDNF — SHC1
Pathways - manually collected, often from reviews:
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BioCarta role of erk5 in neuronal survival pathway:
neurotrophin/TRkA complex (NTF3_BDNF_NGFB-NTRK1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
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NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
SHC (SHC1)
(modification, activates)
Li et al., Science 1992, Stephens et al., Neuron 1994, Obermeier et al., EMBO J 1993
Evidence: assay, physical interaction
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NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1)
→
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
(modification, collaborate)
Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
SHC (SHC1)
(modification, activates)
Meakin et al., J Biol Chem 1999, Ong et al., Mol Cell Biol 2000, Dixon et al., Biochim Biophys Acta 2006, Guiton et al., J Biol Chem 1995, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
Zheng et al., J Neurochem 2004
:
In contrast, the tyrosine phosphorylation of
Shc proteins was dramatically
stimulated by
BDNF , with IGF-1 having only a minimal effect
Yang et al., J Neurobiol 2006
:
In LAR-/- neurons,
BDNF induced activation of TrkB,
Shc , AKT, ERK, and CREB was significantly decreased ; while in LAR transfected neurons, BDNF induced CREB activation was augmented
De Vries et al., Cell Signal 2010
:
The double YY706/707FF TrkB mutant in the kinase activation loop also showed reduced basal activity but surprisingly kept its capacity to enhance
BDNF induced interaction with
Shc , though with less efficacy