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MDM2 — RB1

Pathways - manually collected, often from reviews:

• BioCarta p53 signaling pathway: MDM2 → RB/E2F-1 complex (E2F1-RB1) (modification, activates)
  
• BioCarta p53 signaling pathway: MDM2 → RB (RB1) (modification, activates)
• KEGG Cell cycle: MDM2 → RB1 (protein-protein, inhibition)
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → MDM2 (MDM2) (proteasomal ubiquitin-dependent protein catabolic process, collaborate) Uchida et al., EMBO J 2005*
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways Senescence and Autophagy in Cancer: MDM2 → RB1 (inhibition)
• WikiPathways Cell Cycle: MDM2 → RB1 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MDM2 — RB1 Sdek et al., J Biol Chem 2004*
• IRef Bind_translation Interaction: MDM2 — RB1 (affinity chromatography technology) Sdek et al., J Biol Chem 2004*
• IRef Bind_translation Interaction: RB1 — MDM2 (coimmunoprecipitation) Uchida et al., EMBO J 2005*
• IRef Bind_translation Interaction: RB1 — MDM2 (affinity chromatography technology) Uchida et al., EMBO J 2005*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Nguyen et al., EMBO J 2004*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Zheng et al., FASEB J 2012*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Sdek et al., Mol Cell 2005*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Delston et al., Oncogene 2011*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Sdek et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MDM2 — RB1 (direct interaction, pull down) Xiao et al., Nature 1995*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Xiao et al., Nature 1995*
• IRef Biogrid Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Uchida et al., FEBS Lett 2006*
• IRef Biogrid Interaction: MDM2 — RB1 (direct interaction, pull down) Markham et al., EMBO Rep 2006
• IRef Biogrid Interaction: MDM2 — RB1 (direct interaction, pull down) Hsieh et al., Mol Cell 1999*
• IRef Dip Interaction: MDM2 — RB1 (physical association, affinity chromatography technology) Xiao et al., Nature 1995*
• IRef Dip Interaction: MDM2 — RB1 (physical association, coimmunoprecipitation) Xiao et al., Nature 1995*
• IRef Hprd Interaction: Complex of MDM2-TP53-RB1-RB1-TP53-MDM2-TP53-MDM2-RB1 (in vivo) Hsieh et al., Mol Cell 1999*
• IRef Hprd Interaction: Complex of MDM2-RB1-E2F1-RB1-MDM2-E2F1-E2F1-MDM2-RB1 (in vivo) Markham et al., EMBO Rep 2006
• IRef Hprd Interaction: Complex of 36 proteins (in vivo) Maguire et al., Cancer Res 2008
• IRef Hprd Interaction: Complex of MDM4-MDM2-DHFR-MTBP-PSMD10-RB1 (in vivo) Maguire et al., Cancer Res 2008
• IRef Hprd Interaction: RB1 — MDM2 (in vitro) Xiao et al., Nature 1995*
• IRef Intact Interaction: Complex of TP53-RB1-MDM2 (association, anti tag coimmunoprecipitation) Delston et al., Oncogene 2011*
• IRef Intact Interaction: MDM2 — RB1 (physical association, pull down) Markham et al., EMBO Rep 2006
• IRef Intact Interaction: MDM2 — RB1 (physical association, anti bait coimmunoprecipitation) Delston et al., Oncogene 2011*
• IRef Ophid Interaction: MDM2 — RB1 (aggregation, confirmational text mining) Xiao et al., Nature 1995*
• IRef Ophid Interaction: MDM2 — RB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Zhang et al., Proc Natl Acad Sci U S A 2003 (Prostatic Neoplasms) : In PC3 cells, MDM2 inhibition resulted in elevated p21, Bax, and pRb levels and decreased ppRb and E2F1 levels
Uchida et al., EMBO J 2005 (Carcinoma, Non-Small-Cell Lung...) : In this study, we found that Mdm2 , a ubiquitin ligase for p53, promoted ubiquitin dependent degradation of pRB
Zhao et al., BMC cancer 2005 : Mdm2 may directly repress activation by both pRB and Sp1, or activation by NF-Y
Uchida et al., FEBS Lett 2006 : Effects of MdmX on Mdm2 mediated downregulation of pRB
Nitta et al., PloS one 2007 : Consequently, we tested the hypothesis that gankyrin and/or MDM2 are required for enhanced pRB degradation in Lmna-/- fibroblasts ... p14(arf) expression was also insufficient to stabilize pRB or confer cell cycle arrest, suggesting that MDM2 also does not mediate pRB degradation in Lmna-/- cells
Zheng et al., FASEB J 2012 (Colonic Neoplasms...) : Mouse double minute 2 (MDM2) played a critical role in this 5-aza-CdR induced degradation of pRb