◀ Back to RB1

RB1 — TFDP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of E2F1-TFDP1 → RB1 (decreases, RB1 Activity, E2F1/TFDP1 Activity) Wu et al., Mol Cell Biol 1995
  Evidence: Modified assertion
• BioCarta cell cycle: g1/s check point: RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1) → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, collaborate)
  
• BioCarta cell cycle: g1/s check point: RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1) → E2F-1/DP-1 complex (TFDP1-E2F1) (modification, collaborate)
  
• BioCarta cell cycle: g1/s check point: RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1) → CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6) (modification, collaborate)
  
• BioCarta cell cycle: g1/s check point: RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1) → E2F-1/DP-1 complex (TFDP1-E2F1) (modification, collaborate)
  
• KEGG Cell cycle: RB1 → Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2 (protein-protein, dissociation)
  
• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (transcription, activates)
  Nahle et al., Nat Cell Biol 2002
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → RB1/E2F1/DP complex (RB1-E2F1-TFDP2_TFDP1) (transcription, activates)
  Komori et al., EMBO J 2005
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: RB1/E2F1/DP complex (RB1-E2F1-TFDP2_TFDP1) → p14ARF (CDKN2A) (transcription, inhibits) Komori et al., EMBO J 2005
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1) → HDAC1 (HDAC1) (modification, collaborate) Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1) → CHE-1 (AATF) (modification, collaborate) Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC1 (HDAC1) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC1 (HDAC1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CHE-1 (AATF) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CHE-1 (AATF) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: DNMT1 (DNMT1) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Robertson et al., Nat Genet 2000
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: DNMT1 (DNMT1) → RB1/E2F1-3/DP/HDAC1/DNMT1 complex (RB1-HDAC1-DNMT1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Robertson et al., Nat Genet 2000
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/DNMT1 complex (RB1-HDAC1-DNMT1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Robertson et al., Nat Genet 2000
  Evidence: physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (transcription, activates)
  Zhu et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1 (RB1) (modification, collaborate) Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin E1 complex (CDK2-CCNE1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: p21CIP1/CDK2 complex (CDKN1A-CDK2) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, inhibits)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SPI1 complex (RB1-SPI1-E2F3_E2F2_E2F1-TFDP1) → SPI1/GSC complex (SPI1-GSC) (erythrocyte differentiation, activates)
  Konishi et al., Oncogene 1999
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) → HDAC1 (HDAC1) (modification, collaborate) Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → HDAC1 (HDAC1) (modification, collaborate) Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: SUV39H1 (SUV39H1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: SUV39H1 (SUV39H1) → RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Hiebert et al., Genes Dev 1992, Markham et al., EMBO Rep 2006, Bandara et al., Nature 1991, Chellappan et al., Cell 1991, Bagchi et al., Cell 1991, Lees et al., Mol Cell Biol 1993, Kato et al., Genes Dev 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Hiebert et al., Genes Dev 1992, Markham et al., EMBO Rep 2006, Bandara et al., Nature 1991, Chellappan et al., Cell 1991, Bagchi et al., Cell 1991, Lees et al., Mol Cell Biol 1993, Kato et al., Genes Dev 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Hiebert et al., Genes Dev 1992, Markham et al., EMBO Rep 2006, Bandara et al., Nature 1991, Chellappan et al., Cell 1991, Bagchi et al., Cell 1991, Lees et al., Mol Cell Biol 1993, Kato et al., Genes Dev 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F4/DP/CtBP/hPC2 complex (RB1-CTBP1-CBX4-E2F4-TFDP1) → hPC2 (CBX4) (modification, collaborate) Dahiya et al., Mol Cell 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F4/DP/CtBP/hPC2 complex (RB1-CTBP1-CBX4-E2F4-TFDP1) → RB1/E2F4/DP/CtBP complex (RB1-CTBP1-E2F4-TFDP1) (modification, collaborate)
  Dahiya et al., Mol Cell 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: hPC2 (CBX4) → RB1/E2F4/DP/CtBP complex (RB1-CTBP1-E2F4-TFDP1) (modification, collaborate)
  Dahiya et al., Mol Cell 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: MYOD (MYOD1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Novitch et al., Curr Biol 1999
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: CEBPA/BRM/RB1/E2F4 complex (CEBPA-SMARCA2-RB1-E2F4) → E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) (transcription, inhibits)
  Iakova et al., Cell 2003, Hiebert et al., Proc Natl Acad Sci U S A 1989
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F4/DP complex (RB1-E2F4-TFDP1) → CtBP (CTBP1) (modification, collaborate) Dahiya et al., Mol Cell 2001
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F4/DP complex (RB1-E2F4-TFDP1) → RB1/E2F4/DP/CtBP complex (RB1-CTBP1-E2F4-TFDP1) (modification, collaborate)
  Dahiya et al., Mol Cell 2001
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CtBP (CTBP1) → RB1/E2F4/DP/CtBP complex (RB1-CTBP1-E2F4-TFDP1) (modification, collaborate)
  Dahiya et al., Mol Cell 2001
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1 (RB1) (modification, collaborate) Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin A complex (CDK2-CCNA2) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: SPI1 (SPI1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Weintraub et al., Nature 1995
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: TBP (TBP) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Weintraub et al., Nature 1995
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: SUV39H1 (SUV39H1) → RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nielsen et al., Nature 2001, Vandel et al., Mol Cell Biol 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: SUV39H1 (SUV39H1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nielsen et al., Nature 2001, Vandel et al., Mol Cell Biol 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nielsen et al., Nature 2001, Vandel et al., Mol Cell Biol 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: SPI1 (SPI1) → RB1/E2F1-3/DP/SPI1 complex (RB1-SPI1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: SPI1 (SPI1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SPI1 complex (RB1-SPI1-E2F3_E2F2_E2F1-TFDP1) → GSC (GSC) (modification, collaborate) Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SPI1 complex (RB1-SPI1-E2F3_E2F2_E2F1-TFDP1) → SPI1/GSC complex (SPI1-GSC) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SPI1 complex (RB1-SPI1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: GSC (GSC) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: SPI1/GSC complex (SPI1-GSC) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F4/DP complex (RB1-E2F4-TFDP1) → E2F4/DP complex (E2F4-TFDP1) (modification, collaborate)
  Moberg et al., Mol Cell Biol 1996
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F4/DP complex (RB1-E2F4-TFDP1) → RB1 (RB1) (modification, collaborate) Moberg et al., Mol Cell Biol 1996
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F4/DP complex (E2F4-TFDP1) → RB1 (RB1) (modification, collaborate) Moberg et al., Mol Cell Biol 1996
  Evidence: physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (transcription, activates)
  Hernando et al., Nature 2004
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC3 (HDAC3) → RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC3 (HDAC3) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/Elf1 complex (RB1-E2F3_E2F2_E2F1-ELF1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Weintraub et al., Nature 1995, Wang et al., Science 1993
• NCI Pathway Database Regulation of retinoblastoma protein: Elf1 (ELF1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Weintraub et al., Nature 1995, Wang et al., Science 1993
• NCI Pathway Database E2F transcription factor network: PRMT5 (PRMT5) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (transcription, inhibits)
  Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (transcription, activates)
  Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → RB1 (RB1) (transcription, activates) Shan et al., Mol Cell Biol 1994*
  Evidence: mutant phenotype, reporter gene, physical interaction
• Reactome Reaction: RB1 → TFDP1 (reaction) Connell-Crowley et al., Mol Biol Cell 1997
• Reactome Reaction: RB1 → TFDP1 (direct_complex)
• Reactome Reaction: RB1 → TFDP1 (indirect_complex)
• WikiPathways Cell Cycle: RB1 → TFDP1/E2F1/E2F2/E2F3/E2F5/E2F4/RBL1/E2F6/UBE2F (inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TFDP1 — RB1 (physical association, affinity chromatography technology) Binné et al., Nat Cell Biol 2007
• IRef Biogrid Interaction: TFDP1 — RB1 (physical association, affinity chromatography technology) Wu et al., Mol Cell Biol 1995
• IRef Dip Interaction: TFDP1 — RB1 (physical association, coimmunoprecipitation) Wu et al., Mol Cell Biol 1995
• IRef Intact Interaction: Complex of TFDP1-E2F4-RB1 (physical association, isothermal titration calorimetry) Rubin et al., Cell 2005
• IRef Intact Interaction: Complex of TFDP1-RB1-E2F1-RB1 (physical association, pull down) Rubin et al., Cell 2005
• IRef Intact Interaction: Complex of 13 proteins (physical association, pull down) Rubin et al., Cell 2005
• IRef Intact Interaction: Complex of RB1-TFDP1-E2F5 (physical association, pull down) Rubin et al., Cell 2005
• IRef Intact Interaction: Complex of RB1-TFDP1-E2F2 (physical association, pull down) Rubin et al., Cell 2005
• IRef Ophid Interaction: TFDP1 — RB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Helin et al., J Virol 1994 : Our experiments also demonstrate that pRB binding to the E2F-1/DP-1 heterodimer prevents the formation of an E2F-1/DP-1/E4 complex
Bandara et al., EMBO J 1993 : Thus, pRb , which negatively regulates early cell cycle progression and is frequently mutated in tumour cells, and the Rb-related protein p107, bind to and repress the transcriptional activity of DRTF1/E2F