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GNA11 — PLCB2

Pathways - manually collected, often from reviews:

• KEGG Vascular smooth muscle contraction: GNA11/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Gap junction: GNA11/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Cholinergic synapse: GNA11/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Long-term depression: GNA11/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Long-term depression: GNA11/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG GnRH signaling pathway: GNA11/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Chagas disease (American trypanosomiasis): GNA11/GNA14/GNA15/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Amoebiasis: GNA11/GNA14/GNA15/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Calcium signaling pathway: GNA11/GNA14/GNA15/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• NCI Pathway Database Endothelins: None → ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → None (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Plasma membrane estrogen receptor signaling: Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, activates)
  Le Mellay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: PLC beta (PLCB3/PLCB2/PLCB1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database PAR1-mediated thrombin signaling events: Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, activates)
  Hung et al., J Biol Chem 1992
  Evidence: genetic interaction, other species
• NCI Pathway Database Endothelins: None → ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → None (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → p38 alpha (MAPK14) (modification, activates) Aquilla et al., J Biol Chem 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: PLC beta (PLCB3/PLCB2/PLCB1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• Reactome Reaction: GNA11 → PLCB2 (indirect_complex) Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
• Reactome Reaction: GNA11 → PLCB2 (reaction) Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
• WikiPathways GPR40 Pathway: GNA11 → PLCG1/PLCG2/PLCE1/PLCB1/PLCB2/PLCD1/PLCZ1/PLCB3/PLCH1/PLCL1/PLCD3 (activation)
  

Text-mined interactions from Literome

Cunningham et al., Mol Pharmacol 1999 : Protein kinase C-promoted inhibition of Galpha(11) stimulated phospholipase C-beta activity
Paterson et al., Cell Signal 1995 : Concentration of enzyme dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits
Stanners et al., J Biol Chem 1995 : Here, we report TCR.CD3 mediated guanine nucleotide exchange among the 42-kDa G protein alpha subunits of the G alpha q/11 family, their physical association with CD3 epsilon, and the G alpha 11-dependent activation of phospholipase C beta
Waldo et al., Biochem J 1996 : Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit stimulated phospholipase C-beta from avian erythrocytes