Chen et al., Diabetes 2005
(Diabetes Mellitus, Experimental) :
The independent effect of insulin and hyperglycemia on Hsp60 was investigated in primary cardiomyocytes
Franklin et al., International journal of clinical and experimental medicine 2008
:
The present study was designed to ask whether insulin stimulated HSP60 gene expression ... The rate of HSP60 transcription and mRNA accumulation were measured in rat H4IIE hepatoma cells and insulin induced expression of HSP60 was predominantly via the MEK/ERK pathway ... Inhibition of the p38 and PI3K pathways suggest complex feedback interactions of other insulin-, cell stressor- and cytokine- regulated pathways on the primary role of the MEK/ERK signaling in the regulation of HSP60 gene expression by insulin Märker et al., Diabetes 2012
(Inflammation...) :
In SkMCs, Hsp60 activated ERK1/2, JNK, and NF-?B and inhibits insulin signaling and insulin stimulated glucose uptake