Gene interactions and pathways from curated databases and text-mining

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INS — MMP1

Text-mined interactions from Literome

Game et al., Atherosclerosis 2003 : Regulation of MMP-1 expression in vascular endothelial cells by insulin sensitizing thiazolidinediones
Boden et al., Diabetes 2008 (Hyperinsulinism) : FFA augmented the insulin mediated increases in MMP-2 ( from approximately 6- to approximately 11-fold ), MMP-9 ( from approximately 3- to approximately 23-fold ), MT1-MMP ( from approximately 8- to approximately 20-fold ), MMP-2 gelatinolytic activity ( from 2- to 3-fold ), and JNK and p38 mitogen activated protein kinase ( MAPK ) activities but decreased insulin mediated activation of PI3K and ERK1/2