Duan et al., Mol Cell Biol 2004
(Glucose Intolerance...) :
SH2-B , an Src homology 2 (SH2) and pleckstrin homology domain containing adaptor protein, binds via its SH2 domain to insulin receptor in response to insulin ; however, its physiological role remains unclear
Li et al., Endocrinology 2006
(Body Weight...) :
SH2-B and APS, two members of a pleckstrin homology and SH2 domain containing adaptor family, promote both insulin and leptin signaling in a similar fashion in cultured cells
Li et al., Endocrinology 2007
:
In mice, SH2B1 regulates energy and glucose homeostasis by enhancing leptin and insulin sensitivity