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INS — TCF7L2

Text-mined interactions from Literome

Lyssenko et al., J Clin Invest 2007 (Diabetes Mellitus, Type 2...) : Overexpression of TCF7L2 in human islets reduced glucose stimulated insulin secretion
Ahlzén et al., Biochem Biophys Res Commun 2008 (Insulin Resistance...) : Expression of the transcription factor 7-like 2 gene ( TCF7L2 ) in human adipocytes is down regulated by insulin
Loder et al., Biochem Soc Trans 2008 (Diabetes Mellitus) : TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells ... However, the cellular mechanisms by which changes in TCF7L2 levels may affect insulin secretion are unclear ... In the present paper, we describe the use of RNA silencing to investigate the role of TCF7L2 on insulin secretion and gene expression in rodent islets ... We find that reduced TCF7L2 expression reduces glucose simulated insulin secretion and insulin gene expression while slightly potentiating glucose stimulated changes in intracellular free Ca ( 2+ ) concentrations
González-Sánchez et al., Diabetologia 2008 (Diabetes Mellitus, Type 2) : The association with increased proinsulin : insulin ratio after an OGTT suggests that TCF7L2 might be involved in insulin synthesis and processing
da Silva Xavier et al., Diabetes 2009 (Diabetes Mellitus, Type 2) : However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear
Columbus et al., J Endocrinol 2010 (Diabetes Mellitus, Type 2) : The expression of the three Tcf genes ( Tcf7, Tcf7l1, and Tcf7l2 ) in the pancreas was reduced by treatment with insulin or high-fat diet feeding, in contrast to the stimulation of Tcf7l2 expression by insulin in the gut
Ip et al., Am J Physiol Endocrinol Metab 2012 (Wnt Signaling Pathway) : Insulin and feeding stimulated hepatic TCF7L2 expression in vitro and in vivo, respectively