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INS — VAMP2
Text-mined interactions from Literome
Nagamatsu et al., Diabetes 1999
(Diabetes Mellitus, Type 2) :
Decreased expression of
t-SNARE , syntaxin 1, and SNAP-25 in pancreatic beta-cells is
involved in impaired
insulin secretion from diabetic GK rat islets : restoration of decreased t-SNARE proteins improves impaired insulin secretion
Kawanishi et al., J Biol Chem 2000
:
Both syntaxin4 and
VAMP2 are implicated in
insulin regulation of glucose transporter-4 (GLUT4) trafficking in adipocytes as target ( t ) soluble N-ethylmaleimide-sensitive factor attachment protein receptors ( SNARE ) and vesicle ( v ) -SNARE proteins, respectively, which mediate fusion of GLUT4 containing vesicles with the plasma membrane
Huang et al., Am J Physiol Cell Physiol 2001
(Insulinoma...) :
Previous reports showed that cleavage of
vesicle associated membrane protein-2 ( VAMP-2 ) and synaptosomal associated protein of 25 kDa ( SNAP-25 ) by clostridial neurotoxins in permeabilized insulin secreting beta-cells
inhibited Ca ( 2+ ) -evoked
insulin secretion
Braiman et al., Mol Cell Biol 2001
:
Finally, either
insulin or overexpression of PKC zeta
induced serine phosphorylation of the GLUT4-compartment associated
vesicle associated membrane protein 2
Liu et al., J Biol Chem 2003
:
On the other hand, nocodazole partially inhibited
insulin induced translocation of the insulin regulated aminopeptidase and the
vesicle associated membrane protein ( VAMP)-2 without affecting GLUT1 and VAMP-3
Nevins et al., J Biol Chem 2005
:
A direct interaction between Cdc42 and vesicle associated membrane protein 2 regulates
SNARE dependent
insulin exocytosis
Tian et al., Biochem Biophys Res Commun 2008
:
Insulin induces the dissociation of the Synip and Stx4 complex, and then
triggers VAMP2 to interact with Stx4 to form the SNARE complex, thus promoting the vesicle fusion
Lin et al., J Cell Physiol 2011
:
The purpose of this study was to test a hypothesis that T3 promotes glucose uptake via enhancing
insulin induced Akt phosphorylation and
VAMP2 translocation in 3T3-L1 adipocytes ... Akt phosphorylation is necessary for the promoting effects of T3 on
insulin stimulated
VAMP2 translocation
Regazzi et al., EMBO J 1995
:
Taken together, our results show that pancreatic beta-cells express
VAMP-2 and cellubrevin and that one or both of these proteins selectively
control Ca ( 2+ ) -mediated
insulin secretion