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CDH1 — MET
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CDH1
→
Complex of HGF-MET
(decreases)
Crouch et al., Exp Cell Res 2004*
Evidence: In epithelial carcinoma cells, c-Met activation causes the breakdown of E-cadherin cell-cell contacts leading to cell spreading. Hepatocyte growth factor (HGF), a cytokine involved in tumorigenesis and most metastases, initiates cell migration by binding to the protooncogene c-Met receptor.
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NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
HGF(dimer)/MET(dimer) complex (MET)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
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NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
HGF(dimer)/MET(dimer) complex (MET)
→
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
(translocation, collaborate)
Kimura et al., J Biol Chem 2006
Evidence: mutant phenotype
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NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
MET (MET)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004
Evidence: assay
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NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
HGF/MET complex (HGF-MET)
(modification, inhibits)
Qian et al., EMBO J 2004
Evidence: assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Monga et al., Cell Tissue Res 2006
:
Matrigel also
induced an increased association of beta-catenin with
Met ( hepatocyte growth factor receptor ), whereas association with
E-cadherin remained unchanged
Farazi et al., Cancer Res 2006
(Bile Duct Neoplasms...) :
These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression,
c-Met activation , cErbB2 overexpression, down-regulation of membrane associated
E-cadherin , and p53 codon 248 mutation ... These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression,
c-Met activation , cErbB2 overexpression, down-regulation of membrane associated
E-cadherin , and p53 codon 248 mutation
Cossart et al., J Microsc 2008
:
Moreover, they have also shown that previously unknown components discovered during the study of Listeria invasion play a role either in
E-cadherin mediated cell-cell adhesion or
Met signalling