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PLCG2 — TNF

Text-mined interactions from Literome

Chen et al., J Immunol 2000 : These results suggest that, in NCI-H292 epithelial cells, TNF-alpha might activate phospholipase C-gamma2 via an upstream tyrosine kinase to induce activation of PKC-alpha and protein tyrosine kinase, resulting in the activation of NF-kappaB inducing kinase and IKK1/2, and NF-kappaB in the COX-2 promoter, then initiation of COX-2 expression and PGE2 release
Aki et al., Genes Cells 2008 (Calcium Signaling) : Moreover, PLCgamma2 was necessary for the full production of TNF-alpha and IL-6