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GHR — JAK3

Pathways - manually collected, often from reviews:

• KEGG Jak-STAT signaling pathway: CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR → JAK1/JAK2/JAK3/TYK2 (protein-protein, phosphorylation)

Text-mined interactions from Literome

Liang et al., Endocrinology 2000 : Interaction of GH with the cell-surface GH receptor (GHR) causes activation of the GHR associated tyrosine kinase, JAK2 , and consequent triggering of signaling cascades including the STAT, Ras/Raf/MEK1/MAP kinase, and insulin receptor substrate-1(IRS-1)/PI3kinase pathways
Xu et al., Vitam Horm 2009 : Interaction of GH with its cell surface GH receptor (GHR) causes activation of the GHR associated cytoplasmic tyrosine kinase, JAK2 , and activation of several signaling pathways, including the STATs, ERK1/2, and PI3K pathways