◀ Back to LEP

LEP — PTPN11

Pathways - manually collected, often from reviews:

• Reactome Reaction: LEP → PTPN11 (reaction) Carpenter et al., Proc Natl Acad Sci U S A 1998*
• Reactome Reaction: LEP → PTPN11 (indirect_complex) Carpenter et al., Proc Natl Acad Sci U S A 1998*

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 1999 (Obesity) : After cotransfection of Ob-Rb, Janus kinase 2 (JAK2), and SHP-2 into 293T cells, leptin results in direct binding of SHP-2 to the phosphorylated Tyr 985
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : Leptin increases SHP2 phosphorylation and enhances binding of Grb2 to SHP2