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FGF21 — SDC2
Text-mined interactions from Literome
Bodo et al., Eur J Cell Biol 1999
(Craniofacial Dysostosis) :
A regulatory
role of
fibroblast growth factor in the expression of decorin, biglycan, betaglycan and
syndecan in osteoblasts from patients with Crouzon 's syndrome
The et al., Mol Cell 1999
:
In contrast to mutants in other HSPG biosynthesis genes, the activity of the
HSPG dependent
FGF and Wingless signaling pathways are not affected in ttv mutants
Olwin et al., J Cell Biol 1992
:
These results suggest that activation of FGF receptors by acidic, basic or Kaposi 's sarcoma
FGF requires simultaneous binding to a
HSPG and the tyrosine kinase receptor
Quarto et al., J Cell Sci 1994
:
It is noteworthy that
HSPG binding protects FGF-2 from denaturation and proteolytic degradation, provides a matrix bound or cell-surface reservoir of this factor for the cells and is
required for the activation of
FGF high-affinity receptors
Coutts et al., Immunol Cell Biol 1995
:
The recent discovery of the
involvement of
heparan sulfate proteoglycans (HSPG) in the activation of
fibroblast growth factor receptors ( FGFR ) has led to an intensification of study of this field
Hartmann et al., Curr Biol 1998
:
Although a number of growth factors bind cell-surface heparan sulphate proteoglycans ( HSPGs ), the role of this interaction is unclear except for
fibroblast growth factor which
requires HSPG binding for signalling