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NOS2 — PPARG

Text-mined interactions from Literome

Kitamura et al., Neurosci Lett 1999 : PPARgamma activators inhibited iNOS expression by LPS and IFN-gamma ... These results suggest that activation of PPARgamma negatively regulate iNOS expression and positively regulates HO-1 expression in glial cells
Heneka et al., J Neuroimmunol 1999 : Since in other cell types, both NSAIDs and PGJ2 can activate the peroxisome proliferator activated receptor-gamma ( PPARgamma ) and downregulate cytokine levels and iNOS expression, and since CGCs express PPARgamma in vivo and in vitro, our data suggest that activation of CGC PPARgamma mediates iNOS suppression and reduced cell death
Neve et al., Biochem Pharmacol 2000 (Arteriosclerosis) : PPAR gamma activation in macrophages and foam cells inhibits the expression of activated genes such as inducible nitric oxide synthase , matrix metalloproteinase-9 and scavenger receptor A. PPAR gamma may also affect the recruitment of monocytes in atherosclerotic lesions as it is involved in the expression of VCAM-1 and intracellular adhesion molecule-1 in vascular endothelial cells
Mendez et al., Hypertension 2003 : PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes
Weber et al., Am J Physiol Endocrinol Metab 2004 : These findings support a PPARgamma independent mechanism by which PPARgamma ligands impair cytokine signaling and iNOS expression by islets
Chang et al., Kidney Int 2004 (MAP Kinase Signaling System) : Activation of PPAR-gamma by rosiglitazone inhibited AGE induced iNOS expression, nitrite release, and p38 MAPK activation in mesangial cells
Crosby et al., J Pharmacol Exp Ther 2005 : Peroxisome proliferation activated receptor ( PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide ... We report that PPARgamma is not necessary for the inhibition of iNOS by synthetic PPARgamma agonists ... RAW 264.7 macrophages possess little PPARgamma , yet lipopolysaccharide (LPS)/interferon (IFN)gamma induced iNOS was inhibited by synthetic PPARgamma agonists at 20 microM ... These results indicate that PPARgamma is not necessary for inhibition of iNOS expression by synthetic PPARgamma agonists at concentrations over 10 microM
Kim et al., Exp Eye Res 2005 : Troglitazone significantly increased NO production and iNOS expression after 24hr in a dose-and PPARgamma dependent manner
Sato et al., Am J Physiol Gastrointest Liver Physiol 2006 (Reperfusion Injury) : Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel
Shankaranarayanan et al., Cancer Cell 2009 (Breast Neoplasms) : This `` rexinoid apoptosis '' involves activation of both iNOS and eNOS by RXR-PPARgamma and results in production of apoptogenic NO
Ricote et al., Nature 1998 : Here we show that PPAR-gamma is markedly upregulated in activated macrophages and inhibits the expression of the inducible nitric oxide synthase , gelatinase B and scavenger receptor A genes in response to 15d-PGJ2 and synthetic PPAR-gamma ligands