Zakowski et al., Exp Cell Res 2004
(MAP Kinase Signaling System) :
Studies utilizing dominant interfering mutants and pharmacological agents revealed that upon mitogenic stimulation, 3pK is exclusively activated via the classical MAPK cascade, while stress induced activation of 3pK is mainly mediated by p38 Rousseau et al., Oncogene 1997
:
Activation of p38 resulted in activation of MAP kinase activated protein kinase-2/3 and phosphorylation of the F-actin polymerization modulator, heat shock protein 27 (HSP27)