Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
HIF1A
→
CREBBP
(directlyIncreases, CREBBP Activity)
Evidence: O2-dependent hydroxylation of asparagine (N) residue 803 in HIF-1a by the enzyme FIH-1 (factor inhibiting HIF-1) blocks the binding of p300 and CBP to HIF-1a and therefore inhibits HIF-1-mediated gene transcription.
KEGG Pathways in cancer:
EPAS1/HIF1A
→
CREBBP/EP300
(protein-protein, binding/association)