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FOS — MAP3K7
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lee et al., J Biochem Mol Biol 2002
:
TAK1 dependent activation of
AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB
Li et al., J Biol Chem 2003
:
Ectopic expression of a phosphatase negative mutant of PP2Cepsilon, PP2Cepsilon ( D/A ), which acted as a dominant negative form, enhanced both the association between TAK1 and MKK4 or MKK6 and the
TAK1 induced
activation of an
AP-1 reporter gene
Ishizawa et al., Biol Cell 2006
:
xFADD and xRIP1 synergistically
induced the activation of
AP-1 and NF-kappaB, both of which were partially mediated by TRAF2 ( tumour-necrosis-factor-receptor associated factor 2 ) and
TAK1 ( transforming-growth-factor-beta activated kinase 1 )
Yu et al., J Biol Chem 2008
:
Consistently,
TAK1 mutant with alanine substitution of these two residues severely
inhibits IL-1 induced NFkappaB and
AP-1 activities, whereas TAK1 mutant with replacement of these two sites with acidic residues slightly enhances IL-1 induced NFkappaB and AP-1 activities compared with the TAK1 wild-type ... Consistently, TAK1 mutant with alanine substitution of these two residues severely inhibits IL-1 induced NFkappaB and AP-1 activities, whereas
TAK1 mutant with replacement of these two sites with acidic residues slightly
enhances IL-1 induced NFkappaB and
AP-1 activities compared with the TAK1 wild-type
Kumar et al., J Immunol 2009
(Inflammation) :
TAK1 was also
required for the activation of
AP-1 in response to TWEAK
Nijboer et al., Stroke 2009
(Cerebral Infarction...) :
We now show that TAT-NBD treatment
increased HI-induced
AP-1 activation concomitantly with reduced Gadd45beta, XIAP, and increased ( P )
-TAK1 expression
Dey et al., Virology 2011
:
TAK1 regulates NF-?B and
AP-1 activation in airway epithelial cells following RSV infection ... Inhibition of
TAK1 activation, by overexpression of kinase inactive TAK1 or using cells lacking TAK1 expression, significantly
reduced RSV induced NF-?B and
AP-1 nuclear translocation and DNA binding activity, as well as NF-?B dependent gene expression, identifying TAK1 as an important upstream signaling molecule regulating RSV induced NF-?B and AP-1 activation
Jin et al., Dev Biol 2013
:
Second,
MAP3K1 potentiated AP-2a expression and SRF and
AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation