Gene interactions and pathways from curated databases and text-mining

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EGFR — TRAF6

Pathways - manually collected, often from reviews:

  • KEGG Endocytosis: CBL/CBLB/CBLC/ITCH/MDM2/NEDD4/NEDD4L/RNF41/SMURF1/SMURF2/TRAF6/WWP1 → CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET (protein-protein, ubiquination)

Text-mined interactions from Literome

Webster-Cyriaque et al., J Virol 2000 (AIDS-Related Opportunistic Infections...) : Effects induced by activated TRAF signaling that were detected in HLP included activation of NF-kappaB and c-Jun terminal kinase 1 (JNK1) and upregulated expression of epidermal growth factor receptor (EGFR) , CD40, A20, and TRAFs
Miller et al., Mol Cell Biol 1998 : These data suggest that TRAF mediated activation of EGFR expression requires assembly of a complex containing the appropriate stoichiometry of TRAF proteins clustered at the cell membrane with LMP1