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EGFR — TRAF6
Pathways - manually collected, often from reviews:
-
KEGG Endocytosis:
CBL/CBLB/CBLC/ITCH/MDM2/NEDD4/NEDD4L/RNF41/SMURF1/SMURF2/TRAF6/WWP1
→
CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET
(protein-protein, ubiquination)
Text-mined interactions from Literome
Webster-Cyriaque et al., J Virol 2000
(AIDS-Related Opportunistic Infections...) :
Effects
induced by activated
TRAF signaling that were detected in HLP included activation of NF-kappaB and c-Jun terminal kinase 1 (JNK1) and upregulated expression of
epidermal growth factor receptor (EGFR) , CD40, A20, and TRAFs
Miller et al., Mol Cell Biol 1998
:
These data suggest that
TRAF mediated activation of
EGFR expression requires assembly of a complex containing the appropriate stoichiometry of TRAF proteins clustered at the cell membrane with LMP1