◀ Back to TCF21
TCF21 — WNT3A
Text-mined interactions from Literome
Takeda et al., J Biol Chem 2000
(Eye Abnormalities) :
Induction of melanocyte-specific microphthalmia associated
transcription factor by
Wnt-3a
Oshita et al., Genes Cells 2003
:
Furthermore, Daple inhibited
Wnt-3a dependent
activation of
T-cell factor ( Tcf ) transcriptional activity
Koch et al., Clin Cancer Res 2005
(Hepatoblastoma...) :
In human liver tumor cells without beta-catenin mutations, Nkd-1 inhibited the
Wnt-3a activated
Tcf-responsive-luciferase reporter activity, whereas Nkd-1 in hepatoblastomas with beta-catenin mutations had no antagonistic effect
Kiel et al., Bone 2007
:
In vitro,
TCF-Lef activity in
presence of
Wnt3a was significantly reduced in cells expressing LRP5 haplotypes carrying the T allele of exon 10 and 18 compared to the wild-type allele, whereas co-expression of Dkk1 completely inhibited Wnt3a response through all LRP5 haplotypes
Yokoyama et al., Journal of molecular signaling 2007
:
Wnt3a action attenuates phosphoprotein phosphatase-2A activity and
stimulates the
Lef/Tcf-sensitive gene transcription
Shimizu et al., Mol Cell Biol 2008
:
Moreover, we show that
Wnt-3a activation of
LEF/T-cell factor ( TCF ) -dependent transcription depends on beta-catenin but not on plakoglobin ... We also clearly demonstrate that plakoglobin is insufficient for
LEF/TCF dependent transcriptional activation by
Wnt-3a in F9 cells
Bikkavilli et al., J Cell Sci 2008
:
Chemical inhibitors of p38 MAPK ( SB203580 or SB239063 ) and expression of a dominant negative-version of p38 MAPK attenuate
Wnt3a induced accumulation of beta-catenin,
Lef/Tcf-sensitive gene activation, and primitive endoderm formation
Haÿ et al., Mol Cell Biol 2009
:
N-cadherin overexpression in osteoblasts increases N-cadherin-LRP5 interaction, causing increased beta-catenin degradation and altered
TCF/LEF transcription in
response to
Wnt3a
Yokoyama et al., J Cell Sci 2009
:
Treatment with either genistein or Src family kinase inhibitor PP2 attenuates
Wnt3a stimulated
Lef/Tcf transcription activation and primitive endoderm formation ... siRNA induced knockdown of Src likewise attenuates
Lef/Tcf transcription and primitive endoderm formation in
response to
Wnt3a , implicating Src as a positive regulator of Wnt/beta-catenin signaling ... The Y18F mutant of Dvl2 attenuates the
Wnt3a stimulated
Lef/Tcf-sensitive transcriptional response
Finlayson et al., PloS one 2009
(Cell Transformation, Neoplastic...) :
Consequently, knockdown of MRP in EpRas caused loss of tumorigenesis in vivo, and reduced
Wnt3a induced
TCF reporter signaling in vitro
Qiang et al., Br J Haematol 2010
(Multiple Myeloma) :
Finally,
Wnt3a induced
TCF/LEF transcriptional activity suggests that canonical Wnt signalling is active in osteoclasts
Kang et al., PloS one 2010
(Colorectal Neoplasms...) :
Wnt3a stimulated formation of the
beta-catenin/TCF complexes to two functional TCF-4 binding elements within the PLD2 promoter as assessed by chromatin immunoprecipitation assay
Yokoyama et al., Journal of molecular signaling 2012
:
Point mutations of phosphorylation sites of Dvl3 which interfere with
Lef/Tcf-sensitive transcriptional
activation by
Wnt3a are shown to interfere more proximally with the assembly of Dvl3 based supermolecular complexes