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AKT2 — FOS

Pathways - manually collected, often from reviews:

• WikiPathways Insulin Signaling: GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2 → SRF/ELK1/FOXO1/FOS/JUN/FOXO3/EGR1 (activation)
  

Text-mined interactions from Literome

Bozinovski et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
Mendoza-Gamboa et al., Oncol Rep 2004 (Breast Neoplasms) : Inhibition of HER2/Grb2/Akt decreased AP-1 binding activity in HER2 transfected cells, but increased AP-1 activity in cells that are naturally HER2 overexpressing
Chandrasekar et al., J Biol Chem 2005 : Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression
Wang et al., Cancer Res 2005 (MAP Kinase Signaling System) : Because PTEN is a well-known phosphatase involved in the regulation of phosphatidylinositol 3-kinase (PI-3K)/Akt signaling pathway, taken together with the evidence that PI-3K/Akt plays an important role in the activation of AP-1 and NF-kappaB during tumor development, we anticipate that inhibition of AP-1 and NF-kappaB by tumor suppressor p53 seems to be mediated via PTEN, which may be a novel mechanism involved in anticancer activity of p53 protein
Liao et al., Neurochem Int 2007 : The inductive action of manganese was accompanied by generation of oxidative stress, activation of mitogen activated protein kinases ( MAPKs ), AKT , and protein kinase C-alpha (PKC-alpha), and increased NF-kappaB and AP-1 DNA binding activities
Kim et al., Biol Pharm Bull 2007 (Atherosclerosis) : Pre-treatment of VSMCs with NQ304 ( 1-10 microM ) was found to significantly inhibit the 5 % FBS induced phosphorylations of ERK1/2 and Akt , the activation of AP-1 and the expression of c-fos
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Kim et al., Carcinogenesis 2008 (Breast Neoplasms) : 15d-PGJ ( 2 ) -induced COX-2 expression was mediated by activation of Akt and subsequently activator protein-1 (AP-1)
Lin et al., Rheumatol Int 2008 (Chondrosarcoma...) : Using chondrosarcoma cells stimulated with IL-1beta, the effects of GLN on the mRNA and protein levels of MMP-3, the activation of JNK, ERK, p38, NF-kappaB, and AP-1 , the nuclear translocation of NF-kappaB/Rel family members, and PI3-kinase/Akt activation were studied
Park et al., Biochem Pharmacol 2008 (Bone Resorption) : In conclusion, bavachalcone inhibits osteoclastogenesis by interfering with the ERK and Akt signaling pathways and the induction of c-Fos and NFATc1 during differentiation
Han et al., Toxicol Appl Pharmacol 2008 : Phosphatidylinositol 3 (PI3)-kinase, its downstream signaling molecule, Akt , and mitogen activated protein kinases ( MAPK ) were also significantly activated by the o, p'-DDT induced AP-1 and CRE activation
Hou et al., J Cell Biochem 2009 : US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor ... US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor
Wu et al., J Am Soc Nephrol 2009 (Diabetes Mellitus, Experimental...) : PKC is known to mediate glucose induced TGF-beta1 upregulation through the transcription factor AP-1 ; here, inhibitors of phosphoinositide-3-OH kinase, PKC-beta and Akt, and dominant negative Akt all prevented glucose induced activation of AP-1 and upregulation of TGF-beta1
Park et al., Carcinogenesis 2009 (Breast Neoplasms...) : KPS-A decreased PMA induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA induced phosphorylation of ERK1/2 and Akt
Shrotriya et al., Cancer Res 2010 (Skin Neoplasms) : Diallyl trisulfide inhibits phorbol ester induced tumor promotion, activation of AP-1 , and expression of COX-2 in mouse skin by blocking JNK and Akt signaling ... Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos , and inhibition of COX-2 expression in TPA treated mouse skin ... Taken together, the inhibitory effects of DATS on TPA induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor promoting effect on mouse skin carcinogenesis
Vlahos et al., Am J Respir Crit Care Med 2010 (Pneumonia) : We have previously shown that granulocyte/macrophage colony stimulating factor ( GM-CSF ) regulates lung innate immunity to LPS through Akt/Erk activation of nuclear factor-kappaB and activator protein (AP)-1
Chung et al., Dig Dis Sci 2012 (Colorectal Neoplasms...) : Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells ... These results indicate that knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells
Chen et al., PloS one 2012 : HGF mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element was reduced by c-Met inhibitor, Ly294002, Akt inhibitor, and PP2