◀ Back to TNFSF10

FADD — TNFSF10

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CASP8-FADD-IKBKG-RALBP1-TRAF2 → TNFSF10 (increases) Varfolomeev et al., J Biol Chem 2005*
  Evidence: Here we show that Apo2L/TRAIL activates kinase pathways by promoting the association of a secondary signaling complex, subsequent to assembly of a primary, death-inducing signaling complex (DISC). The secondary complex retained the DISC components FADD and caspase-8, but recruited several factors involved in kinase activation by TNF, namely, RIP1, TRAF2, and NEMO/IKKgamma.
• OpenBEL Selventa BEL large corpus: FADD → TNFSF10 (increases) Rokhlin et al., Oncogene 2001*
  Evidence: PC-3 cells overexpressing FADD dominant negative form were found to be resistant to cell death induced by TRAIL.
• NCI Pathway Database TRAIL signaling pathway: Caspase 10 (CASP10) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Clancy et al., Proc Natl Acad Sci U S A 2005, Mérino et al., Mol Cell Biol 2006, Pan et al., Science 1997, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → Caspase 10 (tetramer) complex (CASP10) (modification, activates)
  Clancy et al., Proc Natl Acad Sci U S A 2005, Mérino et al., Mol Cell Biol 2006, Pan et al., Science 1997, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → TRAILR4 (trimer) complex (TNFRSF10D) (modification, activates)
  Clancy et al., Proc Natl Acad Sci U S A 2005, Mérino et al., Mol Cell Biol 2006, Pan et al., Science 1997, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, inhibits)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR1/DAP3/GTP complex (TNFRSF10A-TNFSF10-DAP3) (modification, collaborate)
  Miyazaki et al., Nat Immunol 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Miyazaki et al., Nat Immunol 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP complex (TNFRSF10A-TNFSF10-DAP3) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Miyazaki et al., Nat Immunol 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR1 complex (TNFRSF10A-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) → TRAIL/TRAILR1 complex (TNFRSF10A-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, inhibits)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: RIP (RIPK1) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: RIP (RIPK1) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRADD (TRADD) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRADD (TRADD) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10B-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → MEKK1 (MAP3K1) (modification, activates) Hu et al., J Biol Chem 1999
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10A-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → MEKK1 (MAP3K1) (modification, activates) Hu et al., J Biol Chem 1999
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAF2 (TRAF2) → TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAF2 (TRAF2) → TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10A-FADD-TRADD-RIPK1-TRAF2-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10A-FADD-TRADD-RIPK1-TRAF2-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 10 (CASP10) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Pan et al., Science 1997, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR2 complex (TNFRSF10B-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2 complex (TNFRSF10B-TNFSF10) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
  Evidence: mutant phenotype, assay, reporter gene
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10B-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → TRAF2 (TRAF2) (modification, collaborate) Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10B-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAF2 (TRAF2) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → TRADD (TRADD) (modification, collaborate) Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → RIP (RIPK1) (modification, collaborate) Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRADD (TRADD) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: RIP (RIPK1) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: Erk1-2-active (MAPK3/MAPK1) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, inhibits)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: FADD → TNFSF10 (indirect_complex) Sprick et al., Immunity 2000, Kohlhaas et al., J Biol Chem 2007*
• Reactome Reaction: FADD → TNFSF10 (reaction) Sprick et al., Immunity 2000, Kohlhaas et al., J Biol Chem 2007*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FADD — TNFSF10 (physical association, affinity chromatography technology) Bellail et al., Cancer Discov 2012
• IRef Biogrid Interaction: FADD — TNFSF10 (physical association, affinity chromatography technology) Bangert et al., Oncogene 2012*
• IRef Biogrid Interaction: FADD — TNFSF10 (physical association, affinity chromatography technology) Jennewein et al., Oncogene 2012
• IRef Intact Interaction: Complex of TNFRSF10B-TNFSF10-FADD-CASP8 (association, pull down) Sprick et al., Immunity 2000
• IRef Intact Interaction: Complex of 21 proteins (association, anti bait coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of 13 proteins (association, coimmunoprecipitation) Sprick et al., EMBO J 2002*
• IRef Intact Interaction: Complex of 11 proteins (association, anti tag coimmunoprecipitation) Unterkircher et al., Clin Cancer Res 2011*
• IRef Intact Interaction: Complex of 43 proteins (association, anti tag coimmunoprecipitation) Bangert et al., Oncogene 2012*
• IRef Intact Interaction: Complex of TNFRSF10B-TNFSF10-CFLAR-CASP8-FADD-CASP10 (association, pull down) Horova et al., FEBS J 2013
• IRef Intact Interaction: Complex of 16 proteins (association, anti tag coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of FADD-TNFSF10-FADD-TNFSF10-TNFRSF10A-CASP8-TNFRSF10A-CASP8 (association, pull down) Sprick et al., Immunity 2000

Text-mined interactions from Literome

Werner et al., J Biol Chem 2002 : We conclude that FADD , caspase-8/10, and caspase cleaved Bid are required for TRAIL receptor and CD95 signaling to mitochondria, whereas Bax is a common accessory
Jin et al., Mol Cell Biol 2006 : Analysis of KD cells indicates that FADD is necessary for Fas-L- or TRAIL- but not TNF induced apoptosis
Yanase et al., Oncol Rep 2007 (Lymphoma, B-Cell) : IFN-alpha induced upregulation of TRAIL protein in the dnFADD expressing Daudi or U266 cells was comparable to their control cells, suggesting that FADD is not involved in the IFN-alpha induced upregulation of TRAIL
Shankar et al., Mol Cancer Ther 2008 (Neoplasm Metastasis...) : Dominant negative FADD inhibited the synergistic interaction between DATS and TRAIL on apoptosis
Hong et al., Neoplasia (New York, N.Y.) 2013 (Adenocarcinoma...) : The AXL/DR5 association had no negative effect on TRAIL induced interaction with FADD
Marsters et al., Curr Biol 1996 : Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA