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PHKA2 — RB1CC1

Text-mined interactions from Literome

Ueda et al., J Cell Biol 2000 : FIP200 also inhibited the kinase activity of the Pyk2 isolated from SYF cells ( deficient in Src, Yes, and Fyn expression ) and the Pyk2 mutant lacking binding site for Src, suggesting that it regulated Pyk2 kinase directly rather than affecting the associated Src family kinases ... Consistent with its inhibitory effect in vitro, FIP200 inhibited activation of Pyk2 and Pyk2 induced apoptosis in intact cells, which correlated with its binding to Pyk2
Wang et al., PloS one 2011 (Glioblastoma) : In the human glioblastoma tumor cells, immortalized human astrocytes, and primary human brain MvEC, we found that downregulation of FIP200 increased the activity of Pyk2 without increasing its expression, but did not affect the activity or expression of FAK