Gene interactions and pathways from curated databases and text-mining

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EGF — ELK1

Text-mined interactions from Literome

Wong et al., J Biol Chem 1999 : Conversely, overexpression of ErbB2- ( 1-813 ) inhibited EGF stimulated Elk-1 transactivation in c'1000 but not in WT cells
Groot et al., Eur J Cell Biol 2000 (Insulinoma...) : In INS-1 cells, however, the activity of the GAL4-Elk1 fusion protein was induced by NGF, but not by EGF
Bernal-Mizrachi et al., Am J Physiol Endocrinol Metab 2001 (Insulinoma) : EGF induced activation of Elk-1 was also inhibited by PD98059 ( 60 +/- 5 % )
Tyagi et al., Oncogene 2003 (Adenocarcinoma...) : GSE treatment of cells also inhibited both EGF induced and constitutively active Elk1 phosphorylation and AP1 activation
Kolli et al., J Biol Chem 2004 : Using MVP-deficient fibroblasts, we demonstrate that MVP cooperates with Ras for optimal EGF induced Elk-1 activation and is required for cell survival
Mahimainathan et al., American journal of physiology. Renal physiology 2005 : In addition to activating PI3-kinase signaling, EGF increased Erk1/2 MAPK activity, leading to transcriptional activation of its nuclear target Elk-1 and resulting in c-fos expression
Bennett et al., Mol Cell Biol 1996 : An SHPTP2 mutant with both C-terminal tyrosyl phosphorylation sites converted to phenylalanine ( PTP2YF ) was also without effect ; moreover, PTP2YF rescued PTP2CS induced inhibition of EGF induced Elk-1 transactivation