Gene interactions and pathways from curated databases and text-mining

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EGF — PAF1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PAF1 → EGF (decreases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Ma et al., Zhonghua Yan Ke Za Zhi 2004 : RT-PCR results revealed that PAF at 100 nmol/L decreased the HGF mRNA expression 4.1 times in RCK and HGF-R 3.5 times in RCE at 24 h compared to control group, while PAF had no effect on the expression of KGF and EGF in RCE cells
Zhou et al., Am J Physiol Heart Circ Physiol 2007 : PAF ( 10 nM ) induced phosphorylation of epidermal growth factor receptor (EGFR)
Slama et al., Prostaglandins 1993 (Placenta Diseases) : Oxytocin, PAF , EGF and A23187 increased only PGIM production in the control animals ; A23187 also decreased TBX2 synthesis